CLINICAL AND DEMOGRAPHIC PROFILE OF PATIENTS WITH PSORIASIS AND ITS EFFECT ON THE QUALITY OF LIFE USING DERMATOLOGY QUALITY OF LIFE INDEX: A CROSS SECTIONAL STUDY
Main Article Content
Abstract
OBJECTIVES: To determine clinical and demographic patterns among patients with psoriasis and their effects on quality of life (QoL) using Dermatology Quality of Life Index (DLQI).
METHODS: This cross-sectional study was conducted at Khyber teaching hospital Peshawar, Pakistan from September 2016 to October 2017. Consecutive sampling technique was used to select 168 patients with psoriasis. DLQI used on all patients, was split in to two groups and score >10 was taken as very large effect on patient's life. Data was analyzed through SPSS v.20 software.
RESULTS: Out of total 168 patients, 115 (68.5%) were female. Plaque was the commonest (n=106; 63.1%) type of psoriasis followed by guttate (n=24; 14.3%) and palmoplantar (n=24; 14.3%). Majority of psoriasis were young adults (n=60; 35.7%), followed by adults (n=56; 33.3%). Mean DLQI score was 10.98±4.300. Group-1 (DLQI score=0-10) included 86 (51.2%) patients and Group-2 (DLQI score >10) included 82 (48.8%) patients. A significant mean difference was recorded among the two groups of DLQI and age of the patient on Independent sample t-test {t (167) =-15.432, p = 0.000}. In group-1, 59 (51.3%) were female and 27 (50.9%) were males; while in group-2, 56 (48.7%) were females and 26 (49.1%) were males.
CONCLUSION: Psoriasis is almost twice more common in female and plaque psoriasis is the commonest variety. Psoriasis has a very large effect on QoL in almost half of the patients. Impact of psoriasis on QoL of the patient is the same in both genders and is more for the erythrodermic form of psoriasis.
Article Details
Work published in KMUJ is licensed under a
Creative Commons Attribution 4.0 License
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
References
Tollefson MM, Crowson CS, McEvoy MT, Maradit Kremers H. Incidence of psoriasis in children: a population based study. J Am Acad Dermatol 2010 June;62(6):979-87. DOI: 10.1016/j.jaad.2009.07.029.
Mercy K, Kwasny M, Cordoro KM, Menter A, Tom WL, Korman N, et al. Clinical manifestations of pediatric psoriasis: results of a multicenter study in the United States. Pediatr Dermatol 2013;30(4):424–8. DOI: 10.1111/pde.12072.
Dubertret L, Mrowietz U, Ranki A, van de Kerkhof PC, Chimenti S, Lotti T, et al. European patient perspectives on the impact of psoriasis: the EUROPSO patient membership survey. Br J Dermatol 2006;155(4):729–36. DOI: 10.1111/j.1365-2133.2006.07405.x.
Grozdev I, Kast D, Cao L, Carlson D, Pujari P, Schmotzer B, et al. Physical and mental impact of psoriasis severity as measured by the compact Short Form-12 Health Survey (SF-12) quality of life tool. J Invest Dermatol 2012;132(4):1111-6. DOI: 10.1038/jid.2011.427.
Braun-Falco O, Pelwig G, Wolff HH, Landthaler M. Burdorf WHC Braun-Falco´s Dermatology. Springer-Verlag Berlin Heidelberg; 2009.
Bhutto AM. Childhood psoriasis: A review of literature. J Pak Assoc Derma 2011;21(3):190-97.
Kormeili T, Lowe NJ, Yamauchi PS. Psoriasis: Immunopathogenesis and evolving immunomodulators and systemic therapies; US experiences. Br J Dermatol 2004;151(1): 3-15. DOI: 10.1111/j.1365-2133.2004.06009.x.
Busch AL, Landau JM, Moody MN. Pediatric psoriasis. Skin Ther Lett 2012;17(1):5-7.
Finlay AY, Khan GK. Dermatology Life Quality Index (DLQI)—a simple practical measure for routine clinical use. Clin Exp Dermatol 1994;19(3):210–6. DOI: 10.1111/j.1365-2230.1994.tb01167.x.
Fuji RK, Mould JF, Tang B, Brandt H, Pomerantz D, Chapnick J, et al. Burden of disease in patients with diagnosed psoriasis in Brazil: results from 2011 national health and wellness survey (NHWS). Value Health 2012;15(4):A107. DOI: 10.1016/j.jval.2012.03.580.
Stern RS, Nijsten T, Feldman SR, Margolis DJ, Rolstad T. Psoriasis is common, carries a substantial burden even when not extensive, and is associated with widespread treatment dissatisfaction. J Investig Dermatol Symp Proc 2004;9(2):136–9. DOI: 10.1046/j.1087-0024.2003.09102.x.
Kimball AB, Jacobson C, Weiss S, Vreeland MG, Wu Y. The psychosocial burden of psoriasis. Am J Clin Dermatol 2005;6(6):383–92. DOI: 10.2165/00128071-200506060-00005.
De Korte J, Sprangers MA, Mombers FM, Bos JD. Quality of life in patients with psoriasis: a systematic literature review. J Investig Dermatol Symp Proc 2004;9(2):140–7. DOI: 10.1046/j.1087-0024.2003.09110.x.
Zachariae H, Zachariae R, Blomqvist K, Davidsson S, Molin L, Mørk C, et al. Quality of life and prevalence of arthritis reported by 5,795 members of the Nordic Psoriasis Associations. Data from the Nordic Quality of Life Study. Acta Derm Venereol 2002;82 (2):108–13. DOI: 10.1080/00015550252948130.
Krueger G, Koo J, Lebwohl M, Menter A, Stern RS, Rolstad T. The impact of psoriasis on quality of life: results of a 1998 National Psoriasis Foundation patient-membership survey. Arch Dermatol 2001;137(3):280–84. DOI: 10-1001/pubs.Arch Dermatol.-ISSN-0003-987x-137-3-dst0024.
Institute for Health Metrics and Evaluation. The Global Burden of Disease: Generating Evidence, Guiding Policy. Seattle, WA: IHME, 2013. [Cited on: May 29S, 2019]. Available on: https://www.healthdata.org/sites/default/files/files/policy_report/2013/GBD_GeneratingEvidence/IHME_GBD_GeneratingEvidence_FullReport.pdf.
Hagg D, Sundstrom A, Eriksson M, Schmitt-Egenolf M. Severity f Psoriasis Between Men and Women: A Study of Clinical Outcome Measure Psoriasis Area and Severity Index (PSAI) in 5438 Swedish Register Patients. Am J Clin Dermatol 2017;18(4):583-90. DOI: 10.1007/s40257-017-0274-0.
Mohd-Affandi A, Khan I, Ngah-Saaya N. Epidemiology and clinical Features of Adult Patients with Psoriasis in Malaysia: 10 Years Review from the Malaysian Psoriasis Registry (2007-2016). Dermatol Res Pract 2018;2018:43714711. DOI: 10.1155/2018/4371471.
Valenzuela F, Silva P, Valdés MP, Papp K. Epidemiology and quality of life of patients with psoriasis in Chile. Actas Dermosifiliogr 2011;102(10):810-16. DOI: 10.1016/j.ad.2011.03.022.