EFFECTS OF ADMINISTRATION OF TARAXACUM OFFICINALE’S EXTRACT ON RENAL PARAMETERS IN CISPLATIN INDUCED NEPHROTOXICITY IN ALBINO MICE

Keywords

Taraxacum
Taraxacum Officinale
Biomarkers
Cisplatin
Nephrotoxicity
Herbal drugs
Urea
Creatinine
Antioxidants

How to Cite

Javaid, A., Zafar, S., Khattak, M., Khan, F., & Wadud, S. (2019). EFFECTS OF ADMINISTRATION OF TARAXACUM OFFICINALE’S EXTRACT ON RENAL PARAMETERS IN CISPLATIN INDUCED NEPHROTOXICITY IN ALBINO MICE. KHYBER MEDICAL UNIVERSITY JOURNAL, 11(3). https://doi.org/10.35845/kmuj.2019.19172

Abstract

OBJECTIVE: To assess biochemical markers after administering Taraxacum officinale’s extract in cisplatin induced nephrotoxic albino mice.

METHODS: It was an experimental study, carried out on thirty albino mice categorized into six groups i-e: normal control (saline only), negative control (cisplatin-25mg/kg body weight intraperitoneally) and experimental groups (E1 to E4) (Taraxacum officinale’s extract at doses 100 mg, 200 mg, 400 mg and 800 mg per kg body weight respectively intraperitoneally followed by single dose of cisplatin-25 mg/kg body weight intraperitoneally). Effects of Taraxacum officinale’s extract on kidney were assessed by biochemical markers i-e blood urea and creatinine.

RESULTS: Comparison of blood urea levels in experimental groups (E1, E2, E3 & E4) was much lowered (242±36.6 mg/dl, 176.8±23.9 mg/dl, 179.4±69.5 mg/dl, 186.6±69.05 mg/dl respectively) than the negative control (363±111.1 mg/dl) [p value < 0.05]. Comparison of serum creatinine in negative control versus experimental groups respectively was decreased but statistically insignificant (serum creatinine levels of experimental groups were 1.60±0.65 mg/dl, 1.89±0.32 mg/dl, 1.66±0.62 mg/dl, 1.84±0.55 mg/dl while serum creatinine of negative control was 1.97±1.06 mg/dl) [p value > 0.05].

CONCLUSION: Taraxacum officinale’s extract (dandelion) significantly reduce the effects of renal toxicity produced by the cisplatin but was unable to completely revert cisplatin-induced nephrotoxicity in mice.

https://doi.org/10.35845/kmuj.2019.19172

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