EFFECTIVENESS OF HERBAL COMBINATION OF IVY, THYME AND CISTI EXTRACTS IN MANAGEMENT OF ACUTE COUGH IN CHILDREN AND ADULTS

Main Article Content

Muhammad Nasir Rana
Muhammad Khalid Masood
Uzma Fahim
Anum Sohail Siddiqui

Abstract

OBJECTIVE: To determine the efficacy of herbal combination of Ivy, Thyme and Cisti extracts in management of acute cough in children and adults.


METHODS: An open label study was conducted to assess the efficacy of herbal combination of Ivy, Thyme and Cisti extracts in relieving acute cough. It was conducted from 1st December 2017 till 28th February 2018 in Children’s Hospital and Services Institute of Medical Sciences, Lahore and Saifee Hospital, Karachi, Pakistan. It was completed by 157 participants of age 2-75 years who reported their cough frequency, severity, and bothersomeness score on a Likert scale of 0 (not at all) to 6 (extremely). Data was entered and analyzed using SPSS v.21.


RESULTS: There were 53.5% males and 46.5% females with mean age of 20.1±19.1 years. The most common clinical features with cough were sputum (70%) and fever (70%). The age group 2-12 years included 53.5% patients who showed significant improvement in frequency (from 4.33±1.13 to 0.69±0.97 in night time and 3.98±1.00 to 0.58±0.88 in daytime), severity (from 4.19±0.99 to 0.65±0.91 in night time and 3.99±1.13 to 0.44±0.84 in daytime), and bothersomeness (from 4.04±1.08 to 0.46±0.83 in night time and 3.86±1.15 to 0.48±0.85 in daytime) with three days of therapy with of Ivy, Thyme and Cisti extracts syrup. No side effect was reported with three days of therapy.


CONCLUSION: Our study concluded that herbal combination of Ivy, Thyme, and Cisti extracts is an efficacious natural cough suppressant in terms of frequency, severity and bothersomeness of cough.

Article Details

How to Cite
Rana, M. N., M. K. Masood, U. Fahim, and A. S. Siddiqui. “EFFECTIVENESS OF HERBAL COMBINATION OF IVY, THYME AND CISTI EXTRACTS IN MANAGEMENT OF ACUTE COUGH IN CHILDREN AND ADULTS”. KHYBER MEDICAL UNIVERSITY JOURNAL, vol. 11, no. 3, Sept. 2019, pp. 165-9, doi:10.35845/kmuj.2019.18883.
Section
Original Articles

References

Irwin RS, French CT, Lewis SZ, Diekemper RL, Gold PM, Adams TM, et al. Overview of the management of cough: CHEST guideline and expert panel report. Chest 2014;146(4):885-9. DOI: 10.1378/chest.14-1485.

Irwin RS, Madison JM. The diagnosis and treatment of cough. New Engl J Med 2000;343(23):1715-21. DOI: 10.1056/NEJM200012073432308.

Koo HK, Jeong I, Lee SW, Park J, Kim JH, Park SY, et al. Prevalence of chronic cough and possible causes in the general population based on the Korean National Health and Nutrition Examination Survey. Medicine (Baltimore) 2016 Sep;95(37):e4595. DOI: 10.1097/MD.0000000000004595.

Smith SM, Schroeder K, Fahey T. Over‐the‐counter (OTC) medications for acute cough in children and adults in community settings. Cochrane Database Syst Rev 2014;(11): CD001831. DOI: 10.1002/14651858.CD001831.pub5.

Wagner L, Cramer H, Klose P, Lauche R, Gass F, Dobos G, Langhorst J. Herbal medicine for cough: a systematic review and meta-analysis. Forsch Komplementmed 2015;22(6):359-68. DOI: 10.1159/000442111.

Jahan Y, Mahmood T, Bagga P, Kumar A, Singh K, Mujahid M. Future prospects of cough treatment; herbal medicines v/s modern drugs. Int J Pharm Sci Res 2015 Sep 1;6(9):3689-97.

Schmidt S. Ivy leaf cough mixtures. SA Pharmacist's Assistant 2017 Apr 1;17(2):5-6.

Hegener O, Prenner L, Runkel F, Baader SL, Kappler J, Häberlein H. Dynamics of β2-adrenergic receptor− ligand complexes on living cells. Biochemistry 2004;43(20):6190-9. DOI: 10.1021/bi035928t.

Hosseinzadeh S, Jafarikukhdan A, Hosseini A, Armand R. The application of medicinal plants in traditional and modern medicine: a review of Thymus vulgaris. Int J Clin Med 2015;6(9):635-42. DOI:10.4236/ijcm.2015.69084.

Cos P, Bruyne TD, Hermans N, Apers S, Berghe DV, Vlietinck AJ. Proanthocyanidins in health care: current and new trends. Curr Med Chem 2004;11(10):1345-59. DOI: 10.2174/0929867043365288.

Arts IC, Hollman PC. Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr 2005;81(1):317S-25S. DOI: 10.1093/ajcn/81.1.317S.

Halliwell B, Rafter J, Jenner A. Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not? Am J Clin Nutr 2005;81(1):268S-76S. DOI: 10.1093/ajcn/81.1.268S.

Ehrhardt C, Hrincius ER, Korte V, Mazur I, Droebner K, Poetter A, et al. A polyphenol rich plant extract, CYSTUS052, exerts anti influenza virus activity in cell culture without toxic side effects or the tendency to induce viral resistance. Antiviral Res 2007;76(1):38-47. Doi: 10.1016/j.antiviral.2007.05.002.

Shields MD, Thavagnanam S. The difficult coughing child: prolonged acute cough in children. Cough 2013;9(1):11. DOI: 10.1186/1745-9974-9-11.

Holzinger F, Beck S, Dini L, Stöter C, Heintze C. The diagnosis and treatment of acute cough in adults. Dtsch Ärztebl Int 2014;111(20):356. DOI: 10.3238/arztebl.2014.0356.

Herman AC, Clalit HS. Comparison of Efficacy and Tolerability of Two Cough Syrups in Cough Due to Cold in Children. 2015. In: ClinicalTrials.gov Bethesda (MD): National Library of Medicine (US). [Cited on: Dec 24, 2018]. Available from: https://clinicaltrials.gov/ct2/show/NCT02486835. NLM Identifier: NCT02486835.

Paul IM, Beiler J, McMonagle A, Shaffer ML, Duda L, Berlin CM. Effect of honey, dextromethorphan, and no treatment on nocturnal cough and sleep quality for coughing children and their parents. Arch Pediatr Adolesc Med 2007;161(12):1140-46. DOI: 10.1001/archpedi.161.12.1140.

Paul IM, Yoder KE, Crowell KR, Shaffer ML, McMillan HS, Carlson LC, et al. Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents. Pediatrics 2004;114(1):e85-e90. DOI: 10.1542/peds.114.1.e85.

Sunilson JAJ, Anandarajagopal K, Khan A, Pasha K, Hassan QB, Raja PVK. Antihistaminic evaluation of formulated polyherbal cough syrup. J Med Plant Res. 2013;4(14):1482-85. DOI: 10.5897/JMPR09.234.

Santoro M Jr. Evaluation of Hedera helix as an expectorant in patients with productive cough. A multicenter study over 5850 patients. Rev Bras Med 2011;62(1):47-52.

Fazio S, Pouso J, Dolinsky D, Fernandez A, Hernandez M, Clavier G, et al. Tolerance, safety and efficacy of Hedera helix1 extract in inflammatory bronchial diseases under clinical practice conditions: A prospective, open, multicentre postmarketing study in 9657 patients. Phytomed 2009;16(1):17-24. DOI: 10.1016/j.phymed.2006.05.003.

Hecker M. Efficacy and tolerance of Ivy extract (Prospan®) in patients suffering from respiratory tract diseases. Nat Med 1999;14:28–33.

Büechi S, Vögelin R, von Eiff MM, Ramos M, Melzer J. Open trials to assess aspects of safety and efficacy of a combined herbal cough syrup with Ivy and Thyme. Complement Med Res 2005;12(6):328-32. DOI: 10.1159/000088934.

Marzian O. Treatment of acute bronchitis in children and adolescents. Non-interventional postmarketing surveillance study confirms the benefit and safety of a syrup made of extracts from Thyme and Ivy leaves. MMW Fortschr Med 2007;149(27-28 Suppl):69-74.

Kalus U, Grigorov A, Kadecki O, Jansen JP, Kiesewetter H, Radtke H. Cistus incanus (CYSTUS052) for treating patients with infection of the upper respiratory tract: a prospective, randomised, placebo-controlled clinical study. Antiviral Res 2009;84(3):267-71. DOI: 10.1016/j.antiviral.2009.10.001.