Reviewing neuroimaging techniques to measure quantitative cerebral blood flow in healthy children
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Abstract
Cerebral blood flow (CBF) is a critical physiological parameter for brain development and function in children. This viewpoint reviews the main neuroimaging techniques for quantifying pediatric CBF, including Positron emission tomography (PET), single photon emission computed tomography (SPECT), perfusion Magnetic Resonance Imaging (MRI), Computed Tomography Perfusion, arterial spin labelling (ASL) MRI, and Doppler ultrasound. Each modality has strengths and limitations related to radiation exposure, accessibility, resolution, and quantification. Reported average CBF values vary by technique and increase with age, reflecting neurodevelopment. ASL MRI offers a promising non-invasive method without radiation. Standardizing protocols across modalities and ages with validation against PET is needed. Quantitative CBF imaging provides a valuable window into understanding cerebrovascular changes in normal and abnormal neurodevelopment.
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