OBJECTIVE: To determine the frequency and pattern of primary brain tumors of infancy and childhood in hospitalized patients at neurosurgery department Lady Reading hospital Peshawar.
METHODS: This descriptive cross sectional study was conducted from January 2013 to December 2013 at neurosurgery department Lady Reading hospital Peshawar, Pakistan. Pediatric patients under 14 years with primary brain tumor were included. Data was then collected on a predesigned proforma from the hospital charts, radiographic and histopathological reports and was analyzed for age, gender and tumor morphology.
RESULTS: Out of 66 patients of primary brain tumour during the study period, 31 cases (46.96%) were supratentorial and 35 cases (53.04%) were infratentorial. Most commonly affected age group was 5-9 years and 10-14 years. Both male and female were equally affected with male to female ratio of 1:1. Twenty one cases (31.81%) were glioma, 17 cases (25.76%) were craniopharyngioma, 12 cases (18.18%) were medulloblastoma, 9 cases (13.65%) were ependymoma, 4 cases (6.06%) were choroid plexus papiloma and 3 cases (4.55%) were meningioma. Out of 21 cases of glioma, 11 cases (52.38%) were pilocytic astrocytoma, 7 cases (33.33%) were glioblastoma multiformis (GBM) and 3 cases (14.29%) were brainstem low grade astrocytoma.
CONCLUSIONS: Most of the pediatric primary brain tumours are infratentorial. Glioma is the most common primary brain tumour in children followed by craniopharyngioma, medulloblastoma and ependymoma. The commonest age groups of presentation were 5-9 years and 10-14 years with equal male to female ratio.
KEY WORDS: Glioma (MeSH), Astrocytoma (MeSH), Craniopharyngiomas ((Non-MeSH),), Medulloblastoma (Non-MeSH), Ependymoma (MeSH), Meningioma (MeSH), Papilloma Choroid Plexus (Non-MeSH).
Birch JM, Hartley AL, Teare MD, Blair V, McKinney PA, Mann JR, et al. The inter-regional epidemiological study of childhood cancer (IRESCC): case-control study of children with central nervous system tumours. Br J Neurosurg 1990;4(1):17-25.
Fernbach DJ , Vietti TJ. General aspects of childhood cancer In: Clinical Pediatric Oncology, 4th ed. Mosby Year Book, Mosby Inc, Missouri,1991: 1-10.
Rosemberg S, Fujiwara D. Epidemiology of pediatric tumors of the nervous system according to the WHO 2000 classification: A report of 1,195 cases from a single institution. Childs Nerv Syst 2005;21:940-4.
Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C, et al. Cancer statistics, 2006. CA Cancer J Clin 2006;56:106-30.
Rickert CH, Paulus W. Epidemiology of central nervous system tumors in childhood and adolescence based on the new WHO classification. Childs Nerv Syst 2001;17:503-11.
Ahmed N, Bhurgri Y, Sadiq S, Shakoor KA. Pediatric brain tumours at a tertiary care hospital in Karachi. Asian Pac J Cancer Prev 2007 Jul-Sep;8(3):399-404.
Mosso ML, Colombo R, Giordano L, Pastore G, Terracini B, Magnani C. Childhood cancer registry of the Province of Torino, Italy. Survival, incidence, and mortality over 20 years. Cancer 1992;69(5):1300–6.
Khan AB, McKeen EA, Zaidi SHM. Childhood cancer in Pakistan with special reference to retinoblastoma. J Pak Med Assoc 1983;33:66-9.
Pollack IF. Pediatric brain tumors. Semin Surg Oncol,1999;16:73-90
Packer RJ, Schut LN, Bruce BA (1990). Brain tumors of Posterior cranial fossa in infant and children. InNeurological Surgery, Youmans J.R. (ed.) 2nd ed, Philadelphia WB Saunders Company
Zaman KU. Posterior fossa tumors in children; twenty months experience at PIMS. J Surg, 1990;1:18-20
Nazir S. Supratentorial tumors in children. FCPS dissertation, Islamabad Pakistan Institute of Medical Sciences 1995.
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