AbstractOBJECTIVE: To determine the effect of malarial infection on hemoglobin,total leukocyte count (TLC) and platelet count of patients coming to atertiary care hospital.METHODOLOGY: This descriptive hospital based study was conductedin the Department of Pathology, Postgraduate Medical Institute, HayabatabadMedical Complex Peshawar and Department of Medicine,Khyber Teaching Hospital Peshawar from July 2009 to January 2010.Total of 100 confirmed patients suffering from malaria were selectedthrough convenient non-probability sampling technique. Completeblood counts (CBC) were performed on automated hematology analyzerSysmex KX 21. Thick and thin films stained with Giemsa stain wereprepared to confirm malarial parasite. Statistical analysis was done byusing SPSS version 14.RESULTS: Out of 100 patients, 56% were males and 44% females.Mean age of the patients was 19.76+13.18 years and majority (39%)was in the age range of 1-10 years. Plasmodium vivax found in 54%and plasmodium falciparum in 46% of cases. Automated hematologyanalyzer results showed that mean total leukocyte count (TLC) was7170.40+3919.11/mm3 (minimum 700/mm3 & maximum 22800/mm3),mean hemoglobin was 9.18+3.03g/dl (minimum 2.80 g/dl & maximum16.40 g/dl) and mean platelet count was 143019+125497.83/mm3(minimum 4000/mm3 & maximum 670000/mm3). These results wereconfirmed manually. Anemia was recorded in 66% of cases, leukopeniain 15% cases, leukocytosis in 12% cases, thrombocytopenia in 68%cases and pancytopenia was observed in 9% cases.CONCLUSION: Thrombocytopenia was recorded in majority of thecases followed by anemia and leucopoenia in patients suffering fromplasmodium vivax and plasmodium falciparum malaria.
Rahim F, Younis M. Malaria in children:
clinical profile and response to treatment.
A district level experience. Pak J Med Sci
; 11: 21-5.
Lamb TJ, Brown DE, Potocnik AJ, Langhorne
J. Insights into the immunopathogenesis
of malaria using mouse models.
Expert Rev Mol Med 2006; 8: 1-22.
Yasinzai MI, Kakarsulemankhel JK. Incidence
of human malaria infection in central
areas of Balochistan: Mastung and Khuzdar.
Rawal Med J 2007; 32: 176-8.
Wickramasinghe SN, Abdulla SH. Blood
and bone marrow changes in malaria.
Baillieres Best Pract Res Clin Haematol
; 13: 277-99.
Price RN, Simpson JA, Nosten F, Luxemburger
C, Hkirjaroen L, ter Kuile F,
et al. Factor contributing to anemia after
uncomplicated falciparum malaria. Am J
Trop Med Hyg 2001; 65: 614-22.
Bates I, Ekem I. Hematological aspects
of tropical diseases. In: Hoffbrand AV,
Catovsky D, Tuddenham EGD, (editors).
Postgraduate haematology. 5th ed. Oxford:
Blackwell; 2005. 979-82.
Beg MA, Khan R, Baig SM, Gulzar Z, Hussain
R, Smego RA, Cerebral involvement
in benign tertian malaria. Am J. Trop Med
Hyg 2002;67: 230-3.
Kochar DK, Saxena V, Singh N, Kochar SK,
Kumar SV, Das A. Plasmodium vivax malaria.
Emerg Infect Dis 2005;11(1):132-4.
McGready R, Lee S, Wiladphaingerm J,
Ashley E, Rijken M, Boel M, et al. Adverse
effects of falciparum and vivax malaria and
the saftey of antimalarial treatment in early
pregnancy: A population based study. Lancet
infect dis 2011; 12(5): 388-96.
Kumar S, Melzer M, Dodds P, Watson J,
Ord R. P. vivax malaria complicated by
shock and ARDS. Scand J Infect Dis 2007;
Rifakis PM, Hernandez O, Fernandez
CT, Rodriguez-Morales AJ, Von A, Franco-
Paredes C. Atypical Plasmodium vivax
malaria in a traveler: bilateral hydronephrosis,
severe thrombocytopenia, and
hypotension. J Travel Med 2008; 15(2):
Oh MD, Shin H, Shin D, Kim U, Lee S, Kim
N, et al. Clinical features of vivax malaria.
Am J Trop Med Hyg 2001; 65: 143-6.
Philip JR. Protozoal and helmenthic infections.
In. Current medical diagnosis and
treatment. 21st Ed. Stephen JM, Maxime
AP( Eds), McGraw Hill New York; 2012:
Ladhani S, Low B, Cole AO, Kowuondo K,
Newtom CR. Changes in white blood cells
and platelets in children with falciparum
malaria: Relationship to disease outcome.
Br J Haematol 2002; 119: 839-47.
Akhtar MN, Jamil S, Amjad SI, Butt AR,
Farooq M. Association of malaria with
thrombocytopenia. Ann KE Med Coll
; 11: 536-7.
Mahmood A, Yasir M. Thrombocytopenia:
A predictor of malaria among febrile patients
in Liberia. Infect Dis J 2005; 14: 41-4.
Memon AR, Afsar S. Thrombocytopenia in
hospitalized malaria patients. Pak J Med Sci
; 22: 141-3.
Jain M, Kaur M. Comparative study of
microscopic detection methods and haematological
changes in malaria. Indian J
Pathol Microbiol 2005; 48: 464-7.
Memon IA, Kanth N, Murtaza G. Chloroquine
resistant malaria in children. J Pak
Med Assoc 1998; 48(4): 98-100.
Pukrittayakamee S, Imwong M, Looareesuwan
S, White NJ. Therapeutic responses
to antibacterial drugs in vivax malaria. Acta
Trop 2004; 89 (3): 351-6.
Determinants of relapse periodicity
in Plasmodium vivax malaria
White NJ. Determinants of relapse periodicity
in Plasmodium vivax malaria Malar
J 2011; 10: 297.
Jamaiah I, Rohela M, Nissapatorn V, Khoo
BL, Khoo PS, Radhiyah M, et al. Malaria:
A 10-year (1994-2003) retrospective
study at University Malaya Medical Center
(UMMC), Kuala Lumpur, Malaysia. Southeast
Asian J Trop Med Public Health 2005;
(Suppl) 4): 60-3.
Yasinzai MI, Kakarsulemankhel JK. A study
of prevalence of malaria infection in urban
areas of district Quetta, Pakistan. Pak J
Zool 2004; 36: 76-9.
Yasinzai MI, Kakarsulemankhel JK. Frequency
of malaria infection in Qallat
and Qilla Saifullah district of Balochistan,
Pakistan. Pak J Med Res 2008; 47: 50-4.
Genton B, D’Acremont V, Rare L, Baea K,
Reeder JC, Alpers MP, et al. Plasmodium
vivax and mixed infections are associated
with severe malaria in children: a prospective
cohort study from Papua New Guinea.
PLoS Med 2008; 5: 127.
Al-Hassan NA, Roberts GT. Pattern of
presentation of malaria in a tertiary care
institute in Saudi Arabia. Saudi Med J 2002;
Asif SA. Departmental audit of malaria
control program 2001- 2005 KPK. J Ayub
Med Coll Abbotabad 2008;20: 98-102.
Abro AH, Ustadi AM, Younis NJ, Abdou
AS, Al Hamed D, Saleh AA. Malaria
and Hematological changes. Pak J Med
Sci 2008; 24 (2): 287-91.
Hayat AS, Siddiqui MS, Shaikh N. Thrombocytopenia;
frequency and degree in patients
with falciparum malaria. Professional
Med J Mar 2011; 18(1): 75-79.
Abro AH, Ustadi AM, Younis NJ, Abdou
AS, Al Hamed D, Akaila IS. Jaundice
with hepatic dysfunction in P. Falciparum
malaria. J Coll Physicians Surg Pak 2009;
Khan SJ, Khan FR, Usman M, Zahid S.
Malaria can lead to thrombocytopenia.
Rawal Med J 2008; 33: 183-5.
Jadhav UM, Singhvi R, Shah R. Prognostic
Implications of White Cell Differential
Count and White Cell Morphology in
Malaria. J Post Med 2003; 49 (3): 218-21.
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