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Rozina Habib
Shafiq Ur Rehman
Tariq Zubair
Musaira Tariq


OBJECTIVE: To find-out the association of dyslipidemia with anxiety and depression in patients with polycystic ovarian syndrome (PCOS).

METHODS: This descriptive cross-sectional study was conducted at Mardan Medical Complex, Mardan, Pakistan from December-2019 to March-2020. One hundred & forty diagnosed cases of PCOS, ranging in age from 20-40 years, were selected through purposive sampling. Anxiety and depression were calculated using hospital anxiety and depression scale (HADS) score. Total cholesterol (TC), triglycerides, low-density-lipoproteins (LDL), high-density-lipoproteins (HDL) and testosterone were tested through fasting blood samples.

RESULTS: Anxiety and depression were documented in 102 (72.9%) & 99 (70.7%) cases respectively. Primary infertility, oligomenorrhoea, Hirsutism & acne were present in 69 (49.3%), 111 (73.5%), 81 (57.9%) and 55 (39.3%) patients respectively. Twenty-two (15.7%) patients were overweight/obese. All patients had raised testosterone levels and polycystic ovaries on ultrasound. Raised triglyceride levels (≥150 mg/dl), Low levels of HDL (≤ 60mg/dl), raised levels of LDL (≥130 mg/dl), raised cholesterol levels (≥200 mg/dl) were reported in 71/99 (71.7%), 56/99 (56.6%), 38/99 (38.4%) & 10/99 (10.2%) cases with depression as compared to 27/41 (65.9%), 13/41 (31.7%), 21/41 (51.2%) & 14/41(34.1%) non-depressed patients respectively. Similarly raised triglyceride levels, low levels of HDL, raised levels of LDL, raised cholesterol levels were reported in 73/102 (71.6%), 58/102 (56.9%), 40/102 (39.2%) & 12/102 (11.76%) cases with anxiety as compared to 25/38 (65.8%), 11/38 (28.9%), 19/38 (50%) and 12/38 (31.6%) patients without anxiety respectively.

CONCLUSION: Dyslipidemia, anxiety and depression  are very common in PCOS. Dyslipidemia is associated with anxiety and depression in PCOS patients.

Article Details

How to Cite
Habib, R., S. U. Rehman, T. Zubair, and M. Tariq. “ASSOCIATION OF DYSLIPIDEMIA WITH ANXIETY AND DEPRESSION IN PATIENTS OF POLYCYSTIC OVARIAN SYNDROME”. KHYBER MEDICAL UNIVERSITY JOURNAL, vol. 13, no. 2, June 2021, pp. 113-7, doi:10.35845/kmuj.2021.21298.
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