ROLE OF SALIVARY BIOMARKERS IN DIAGNOSIS OF PERIODONTITIS – A LITERATURE REVIEW

Main Article Content

Hamda Shazam
Fouzia Shaikh
Muhammad Mansoor Majeed
Sadia Khan
Saba Khan

Abstract

Periodontitis, a chronic inflammatory disease of oral cavity, caused by the complex interactions between host immune system and sub-gingival microbiota leading to chronic gingival inflammation, loss of periodontal ligament attachment, dental impairment, and finally tooth loss. Prevalence of periodontal disease varies and reported a higher prevalence in Asian countries. The conventional diagnostic techniques used for periodontitis are inherently limited. Periodontitis immunopathogenesis studies and mediator analyzes in saliva allowed the identification of a number of disease-specific molecular biomarkers. In this review article, diagnostic role of various salivary biomarkers in periodontitis has been discussed. Original articles, systematic and narrative reviews related to relevant study, published since 2009-2019 were included in the literature search through PubMed, Google Scholar, Web of Science and Scopus. Convenient assessments of these salivary biomarkers with analytical chair facilities will yield more accurate diagnostic results which will further aid in early detection and better clinical management of periodontitis patients.

Article Details

How to Cite
Shazam, H., F. Shaikh, M. Majeed, S. Khan, and S. Khan. “ROLE OF SALIVARY BIOMARKERS IN DIAGNOSIS OF PERIODONTITIS – A LITERATURE REVIEW”. KHYBER MEDICAL UNIVERSITY JOURNAL, Vol. 12, no. 4, Dec. 2020, pp. 326-30, doi:10.35845/kmuj.2020.19808.
Section
Narrative Review Articles

References

1. Lundmark A, Johannsen G, Eriksson K, Kats A, Jansson L, Tervahartiala T, et al. Mucin 4 and matrix metalloproteinase 7 as novel salivary biomarkers for periodontitis. J Clin Periodontol 2017 Mar;44(3):247–54. DOI:10.1111/jcpe.12670.
2. Hajishengallis G. Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol 2015;15(1):30–44. DOI: 10.1038/nri3785.
3. Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet 2005;366(9499):1809–20. DOI: 10.1016/S0140-6736(05)67728-8.
4. Taylor JJ. Protein Biomarkers of Periodontitis in Saliva. ISRN Inflamm 2014;2014:1–18.
5. Lange L, Thiele GM, McCracken C, Wang G, Ponder LA, Angeles-Han ST, et al. Symptoms of periodontitis and antibody responses to Porphyromonas gingivalis in juvenile idiopathic arthritis. Pediatr Rheumatol 2016;14(1):8. DOI: 10.1186/s12969-016-0068-6.
6. Chan JF-W, Yuan S, Kok K-H, To KK-W, Chu H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 2020;395(10223):514–23. DOI: 10.1016/S0140-6736(20)30154-9.
7. Borgnakke WS. “Non-modifiable” Risk Factors for Periodontitis and Diabetes. Curr Oral Heal Reports 2016;3(3):270–81. DOI: 10.1007/s40496-016-0098-7.
8. Umeizudike KA, Iwuala SO, Ozoh OB, Ayanbadejo PO, Fasanmade OA. Association between periodontal diseases and systemic illnesses: A survey among internal medicine residents in Nigeria. Saudi Dent J 2016;28(1):24–30. DOI: 10.1016/j.sdentj.2015.03.005.
9. Dye BA. Global periodontal disease epidemiology. Periodontol 2000 2012 Feb;58(1):10–25. DOI:10.1111/j.1600-0757.2011.00413.x
10. Preshaw PM, Henne K, Taylor JJ, Valentine RA, Conrads G. Age-related changes in immune function (immune senescence) in caries and periodontal diseases: a systematic review. J Clin Periodontol 2017;44:S153–77. DOI:10.1111/jcpe.12675.
11. Corbet EF, Leung WK. Epidemiology of periodontitis in the Asia and Oceania regions. Periodontol 2000 2011;56(1):25–64. DOI:10.1111/j.1600-0757.2010.00362.x.
12. White DA, Tsakos G, Pitts NB, Fuller E, Douglas GVA, Murray JJ, et al. Adult Dental Health Survey 2009: common oral health conditions and their impact on the population. Br Dent J 2012;213(11):567–72. DOI: 10.1038/sj.bdj.2012.1088.
13. Mahmud S, Amin M. Association between tobacco consumption and periodontal diseases among type 2 diabetes mellitus patients. Saudi J Oral Sci 2016;3(2):90. DOI: 10.4103/1658-6816.188082.
14. Bokhari SH, Suhail A, Malik A, Imran M. Periodontal disease status and associated risk factors in patients attending a Dental Teaching Hospital in Rawalpindi, Pakistan. J Indian Soc Periodontol 2015;19(6):678. DOI: 10.4103/0972-124X.156882.
15. Lourenço TGB, Heller D, Silva-Boghossian CM, Cotton SL, Paster BJ, Colombo APV. Microbial signature profiles of periodontally healthy and diseased patients. J Clin Periodontol 2014;41(11):1027–36. DOI:10.1111/jcpe.12302.
16. Pérez-Chaparro PJ, Gonçalves C, Figueiredo LC, Faveri M, Lobão E, Tamashiro N, et al. Newly Identified Pathogens Associated with Periodontitis. J Dent Res 2014;93(9):846–58. DOI:10.1177/0022034514542468.
17. Bartold PM, Van Dyke TE. An appraisal of the role of specific bacteria in the initial pathogenesis of periodontitis. J Clin Periodontol 2019;46(1):6–11. DOI:10.1111/jcpe.13046.
18. Kaufman E, Lamster IB. Analysis of saliva for periodontal diagnosis. A review. J Clin Periodontol 2000;27(7):453–65 DOI: 10.1034/j.1600-051x.2000.027007453.x.
19. Ebersole JL, Nagarajan R, Akers D, Miller CS. Targeted salivary biomarkers for discrimination of periodontal health and disease(s). Front Cell Infect Microbiol 2015;5:62. DOI:10.3389/fcimb.2015.00062.
20. Sahibzada HA, Khurshid Z, Khan RS, Naseem M, Siddique KM, Mali M, et al. Salivary IL-8, IL-6 and TNF-α as Potential Diagnostic Biomarkers for Oral Cancer. Diagnostics (Basel) 2017;7(2):21. DOI: 10.3390/diagnostics7020021.
21. Prakasam S, Srinivasan M. Evaluation of salivary biomarker profiles following non-surgical management of chronic periodontitis. Oral Dis 2014;20(2):171–7. DOI:10.1111/odi.12085.
22. Ebersole JL, Schuster JL, Stevens J, Dawson D, Kryscio RJ, Lin Y, et al. Patterns of Salivary Analytes Provide Diagnostic Capacity for Distinguishing Chronic Adult Periodontitis from Health. J Clin Immunol 2013 29;33(1):271–9. DOI:10.1007/s10875-012-9771-3.
23. Costa PP, Trevisan GL, Macedo GO, Palioto DB, Souza SLS, Grisi MFM, et al. Salivary Interleukin-6, Matrix Metalloproteinase-8, and Osteoprotegerin in Patients With Periodontitis and Diabetes. J Periodontol 2010;81(3):384–91. DOI:10.1902/jop.2009.090510.
24. Banu S, Jabir NR, Mohan R, Manjunath NC, Kamal MA, Vinod Kumar KR, et al. Correlation of Toll-Like Receptor 4, Interleukin-18, Transaminases, and Uric Acid in Patients With Chronic Periodontitis and Healthy Adults J Periodontol 2015;86(3):431–9. DOI:10.1902/jop.2014.140414.
25. Al-Sabbagh M, Alladah A, Lin Y, Kryscio RJ, Thomas M V., Ebersole JL, et al. Bone remodeling-associated salivary biomarker MIP-1α distinguishes periodontal disease from health. J Periodontal Res 2012;47(3):389–95. DOI:10.1111/j.1600-0765.2011.01445.x.
26. Özçaka Ö, Nalbantsoy A, Köse T, Buduneli N. Plasma osteoprotegerin levels are decreased in smoker chronic periodontitis patients. Aust Dent J 2010;55(4):405–10. DOI:10.1111/j.1834-7819.2010.01261.x.
27. Graves DT, Li J, Cochran DL. Inflammation and Uncoupling as Mechanisms of Periodontal Bone Loss. J Dent Res 2011;90(2):143–53. DOI:10.1177/0022034510385236.
28. Tobón-Arroyave SI, Isaza-Guzmán DM, Restrepo-Cadavid EM, Zapata-Molina SM, Martínez-Pabón MC. Association of salivary levels of the bone remodelling regulators sRANKL and OPG with periodontal clinical status. J Clin Periodontol 2012;39(12):1132–40. DOI:10.1111/jcpe.12012.
29. Ram VS, Parthiban, Sudhakar U, Mithradas N, Prabhakar R. Bonebiomarkers in periodontal disease: a review article. J Clin Diagn Res 2015;9(1):ZE07-10. DOI: 10.7860/JCDR/2015/11268.5438
30. Miricescu D, Totan A, Calenic B, Mocanu B, Didilescu A, Mohora M, et al. Salivary biomarkers: Relationship between oxidative stress and alveolar bone loss in chronic periodontitis. Acta Odontol Scand 2014;72(1):42–7. DOI:10.3109/00016357.2013.795659
31. Betsy J, Ahmed JM, Mohasin AK, Mohammed A, Nabeeh A. A. Diagnostic accuracy of salivary biomarkers of bone turnover in identifying patients with periodontitis in a Saudi Arabian population. J Dent Sci 2019;14(3):269–76. DOI: 10.1016/j.jds.2019.03.002.
32. Hienz SA, Paliwal S, Ivanovski S. Mechanisms of Bone Resorption in Periodontitis. J Immunol Res 2015;2015: 615486. DOI: 10.1155/2015/615486.
33. Becker KL, Snider R, Nylen ES. Procalcitonin assay in systemic inflammation, infection, and sepsis: Clinical utility and limitations. Crit Care Med 2008;36(3):941–52. DOI: 10.1097/CCM.0B013E318165BABB.
34. Yoon AJ, Cheng B, Philipone E, Turner R, Lamster IB. Inflammatory biomarkers in saliva: assessing the strength of association of diabetes mellitus and periodontal status with the oral inflammatory burden. J Clin Periodontol 2012;39(5):434–40. DOI:10.1111/j.1600-051X.2012.01866.x.
35. Korte DL, Kinney J. Personalized medicine: an update of salivary biomarkers for periodontal diseases. Periodontol 2000 2016;70(1):26–37. DOI:10.1111/prd.12103
36. Rudrakshi C, Mehta D, Srinivas N. A comparative evaluation of hepatocyte growth factor levels in gingival crevicular fluid and saliva and its correlation with clinical parameters in patients with and without chronic periodontitis: A clinico-biochemical study. J Indian Soc Periodontol 2011;15(2):147. DOI: 10.4103/0972-124X.84384.
37. Wilczyńska-Borawska M, Borawski J, Bagińska J, Małyszko J, Myśliwiec M. Hepatocyte Growth Factor in Saliva of Patients with Renal Failure and Periodontal Disease. Ren Fail 2012;34(8):942–51. DOI:10.3109/0886022X.2012.696510
38. Isaza-Guzmán DM, Arias-Osorio C, Martínez-Pabón MC, Tobón-Arroyave SI. Salivary levels of matrix metalloproteinase (MMP)-9 and tissue inhibitor of matrix metalloproteinase (TIMP)-1: A pilot study about the relationship with periodontal status and MMP-9−1562C/T gene promoter polymorphism. Arch Oral Biol 2011;56(4):401–11. DOI: 10.1016/j.archoralbio.2010.10.021.
39. Franco C, Patricia H-R, Timo S, Claudia B, Marcela H. Matrix Metalloproteinases as Regulators of Periodontal Inflammation. Int J Mol Sci 2017;18(2):440. DOI: 10.3390/ijms18020440.
40. Gursoy UK, Könönen E, Pradhan-Palikhe P, Tervahartiala T, Pussinen PJ, Suominen-Taipale L, et al. Salivary MMP-8, TIMP-1, and ICTP as markers of advanced periodontitis. J Clin Periodontol 2010;37(6):487–93. DOI: 10.1111/j.1600-051X.2010.01563.x