OBJECTIVES: To determine the demographic, clinical and radiographic features of the central giant cell granulomas (CGCG) of jaws.
METHODS: This observational study was conducted at Outpatient Department of Oral and Dental Hospital, Khyber College of Dentistry Peshawar and private clinics at Peshawar, Nowshera, Mardan and Kohat, from June 2006 to May 2018. Sixty-eight cases of CGCG of jaws, excluding known patients of syndromes and hyperparathyroidism, confirmed by biopsy were included in this study by convenience sampling.
RESULTS: Age ranged from 4-50 years with mean of 22.35±11.68 years. Most of the patients were from 21-30 years (n=28/68; 41%). CGCG were slightly more frequent in females (n=36/68; 53%) as compared to males (n=32/68; 47%). Anterior part of mandible was the most common site involved (n=32/68; 47.1%). There was cortical expansion in 53 out of 68 cases. Tooth mobility was found in more than half of cases (n=36.68; 52.9%). Only four cases of lip numbness, while no case of spontaneous bleeding (three cases of bleeding on touch were seen). Among all the radiolucencies, majority of CGCG (n= 40/68; 58.8%) had well define borders while 41.2% of CGCG had diffuse borders. Majority of CGCG were unilocular. Tooth resorption was seen in about one-third patients (n=24/68; 35.3%).
CONCLUSION: The clinical and radiographic features of some CGCG show benign features like non-mobile teeth, only buccal cortical expansion, uniloculor radiolucency, no tooth resorption and well define borders. However, some show aggressive features like tooth mobility, bicortical expansion, multiloculor radiolucency, root resorption and ill-defined borders.
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