CLINICAL AND RADIOGRAPHIC PRESENTATION OF CENTRAL GIANT CELL GRANULOMAS OF JAWS

Main Article Content

Umar Nasir
Bibi Maryam
Tehmina Marwat
Neelofar Nausheen

Abstract

OBJECTIVES: To determine the demographic, clinical and radiographic features of the central giant cell granulomas (CGCG) of jaws.
METHODS: This observational study was conducted at Outpatient Department of Oral and Dental Hospital, Khyber College of Dentistry Peshawar and private clinics at Peshawar, Nowshera, Mardan and Kohat, from June 2006 to May 2018. Sixty-eight cases of CGCG of jaws, excluding known patients of syndromes and hyperparathyroidism, confirmed by biopsy were included in this study by convenience sampling.
RESULTS: Age ranged from 4-50 years with mean of 22.35±11.68 years. Most of the patients were from 21-30 years (n=28/68; 41%). CGCG were slightly more frequent in females (n=36/68; 53%) as compared to males (n=32/68; 47%). Anterior part of mandible was the most common site involved (n=32/68; 47.1%). There was cortical expansion in 53 out of 68 cases. Tooth mobility was found in more than half of cases (n=36.68; 52.9%). Only four cases of lip numbness, while no case of spontaneous bleeding (three cases of bleeding on touch were seen). Among all the radiolucencies, majority of CGCG (n= 40/68; 58.8%) had well define borders while 41.2% of CGCG had diffuse borders. Majority of CGCG were unilocular. Tooth resorption was seen in about one-third patients (n=24/68; 35.3%).
CONCLUSION: The clinical and radiographic features of some CGCG show benign features like non-mobile teeth, only buccal cortical expansion, uniloculor radiolucency, no tooth resorption and well define borders. However, some show aggressive features like tooth mobility, bicortical expansion, multiloculor radiolucency, root resorption and ill-defined borders.

Article Details

How to Cite
Nasir, U., B. Maryam, T. Marwat, and N. Nausheen. “CLINICAL AND RADIOGRAPHIC PRESENTATION OF CENTRAL GIANT CELL GRANULOMAS OF JAWS”. KHYBER MEDICAL UNIVERSITY JOURNAL, Vol. 11, no. 4, Dec. 2019, pp. 231-5, doi:10.35845/kmuj.2019.19302.
Section
Original Articles

References

1. Shafer WG, Hine MK, Levy BM, Tomich CE. Benign and malignant tumour of the oral cavity. In: A textbook of oral pathology. 4th ed Philadelphia: WB Saunders 1997; 144-9
2. Yannoulopoulos A, Mavropoulou T. [Giant cell granulomas of the jaws]. Hell Stomatol Chron1988;32(1):43-51.
3. Kelly HC, Seward GR, Kay LW. Giant cell lesions of the jaws. In: An outline of oral surgery, part II. Oxford: Wright 1998; 89-94.
4. Shields JA. Peripheral giant cell granuloma: A review. J Ir Dent Assoc 1994;40:39-41.
5. Ragezi JA, Pogrel MA. Comments on the pathogenesis and medical treatment of central giant cell granulomas. J Oral Maxillofac Surg 2004;62(1):116-8. DOI: 10.1016/j.joms.2003.10.005
6. Chatta MR, Ali K, Aslam A, Afzal B, Shahzad MA. Current concepts in central giant cell granuloma. Pak Oral Dent J 2006;26(1):71-8.
7. Stewart JCB. Benign Nonodontogenic Tumors. In: Regezi JA, Sciubba JJ, Jordan RCK eds. Oral Pathology: Clinical Patho¬logic Correlations. 5th ed. New Delhi: Elsevier 2017;292¬-310.
8. Jaffe HL. Giant cell reparative granuloma, traumatic bone cysts and fibrous (fibro-osseous) dysplasia of jawbones. Oral Surg 1953;6:159-75. DOI: 10.1016/0030-4220(53)90151-0
9. Whitaker SB, Waldron CA. Central giant cell lesions of the jaws. A clinical, radiologic and histopathologic study. Oral Surg Oral Med Oral Pathol 1993; 75: 199-208. DOI: 10.1016/0030-4220(93)90094-k
10. Chuong R, Kaban LB, Kozakewich H, Perez-Atayade A. Central giant cell lesion of the jaws: a clinicopathologic study. J Oral Maxillofac Surg 1986;44:708-13. DOI: 10.1016/0278-2391(86)90040-6
11. Güngormüs M, Akgul HM. Cental giant cell granuloma of the jaws, a clinical and radiologic study. J Contemp Dent Pract 2003;4(3):87-97.
12. Starropoulos F, Katz J. Systematic review central giant cell granulomas: a systematic review of the radiographic characteristics with addition of 20 new cases. Dentomaxillofac Radiol 2002;31(4):213-7. DOI: 10.1038/sj.dmfr.4600700
13. De Lange J, van den Akker HP. Clinical and radiogical features of central giant cell lesions of jaw. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;99(4):464-70. DOI: 10.1016/j.tripleo.2004.11.015
14. Bodner L, Bar-Ziv J. Radiographic features of central giant cell granuloma of the jaws in children. Pediatr Radiol 1996;26(2):148-151. DOI: 10.1007/bf01372096
15. Csillag A, Pharoach M, Gullane P, Mancer K, Disney TV. A central giant cell granuloma influenced by pregnancy. Dentomaxillofac Radiol 1997;26(6):357-60. DOI: 10.1038/sj.dmfr.4600293
16. Cohen MA, Hertzanu Y. Radiologic features, including those seen with computed tomography of central giant cell granuloma of the jaws. Oral Surg Oral Med Oral Pathol 1988;65(2):255-61. DOI: 10.1016/0030-4220(88)90176-4
17. Kaffe I, Ardekian L, Taicher S, Litner MM, Buchner A. Radiologic features of central giant cell granuloma of jaws. Oral Surg Oral Med Oral Pathol 1996;81(6):720-6. DOI: 10.1016/s1079-2104(96)80079-5
18. Horner K. Central giant cell granuloma of the jaws: a clinicoradiological study. Clin Radiol 1989; 40(6):622-6. DOI: 10.1016/s0009-9260(89)80325-3
19. Aghbali A, Sina M, Pakdel SMV, Emamverdizadeh P, Kouhsoltani M, Mahmoudi SM, et al. Correlation of histopathologic features with demographic, gross and radiographic findings in giant cell granulomas of the jaws. J Dent Research Dent Clinic Dent Prospects 2013: 7(4), 225–9. DOI:10.5681/joddd.2013.036
20. Buduru K, Podduturi S, Vankudoth D, Prakash J. Central giant cell granuloma: A case report and review. J Indian Acad Oral Med Radiol 2017:29(2):145-8. DOI: 10.4103/jiaomr.JIAOMR_100_15
21. Reddy V, Saxena S, Aggarwal P, Sharma P, Reddy M. Incidence of central giant cell granuloma of the jaws with clinical and histological confirmation: an archival study in Northern India. Br J Oral Maxillofac Surg 2012:50(7);668-72. DOI: 10.1016/j.bjoms.2011.10.015