EFFECTS OF PROPHYLACTIC MATERNAL DEXAMETHASONE ADMINISTRATION ON THE NEONATAL RESPIRATORY OUTCOMES AT TERM AFTER ELECTIVE CAESAREAN SECTION: RANDOMIZED CONTROLLED TRIAL

Main Article Content

Hasina Sadiq
Irum Sohail

Abstract

OBJECTIVE: To assess the effects of prophylactic antenatal dexamethasone administration in reducing the neonatal respiratory morbidity at term after elective lower segment caesarean section (LSCS).
METHODS: This open label randomized-controlled trial was conducted in Department of Obstetrics and Gynaecology, Kahuta Research Laboratories (KRL) Hospital, Islamabad from September 2017 to February 2018. Patients with singleton pregnancy and non-anomalous fetus between gestational age of 37+0 and 38+6, planned to be delivered by elective LSCS were randomized through block-randomization method into interventional group (A): who received dexamethasone and control group (B): who did not receive prophylactic dexamethasone. Main outcomes of the study included Apgar-score at one & five minutes, admission to neonatal intensive care unit (NICU) due to transient tachypnea of newborn (TTN) and respiratory distress syndrome (RDS). Data was analyzed by SPSS version 23.
RESULTS: A total of 304 women were randomized and equally assigned to interventional and control group. In group-A, 2 neonates developed RDS as compared to one neonate in group-B (p=0.391). Mean age of patients in group A and B was 30.48±4.18 years and 29.38±4.57years respectively. Five-minutes Apgar score was 8.91±0.290 in group A & 8.87±0.393 in group B (p=0.320). TTN developed in four neonates in group-A while one neonate in group-B (p=0.176). Eighteen (11.8%) cases in group A & 12(7.9%) cases in group B were admitted in NICU (p=0.249).
CONCLUSION: Prophylactic dexamethasone administration in term LSCS after 37 weeks of gestational age has no significant effects on reducing the incidence of RDS, TTN and neonatal admission to NICU.

Article Details

How to Cite
Sadiq, Hasina, and Irum Sohail. “EFFECTS OF PROPHYLACTIC MATERNAL DEXAMETHASONE ADMINISTRATION ON THE NEONATAL RESPIRATORY OUTCOMES AT TERM AFTER ELECTIVE CAESAREAN SECTION: RANDOMIZED CONTROLLED TRIAL”. KHYBER MEDICAL UNIVERSITY JOURNAL, vol. 11, no. 1, Mar. 2019, pp. 6-11, doi:10.35845/kmuj.2019.18762.
Section
Original Articles
Author Biographies

Hasina Sadiq, KAHUTA RESEARCH LABORATORIES (KRL), HOSPITAL, ISLAMABAD, PAKISTAN.

POST-GRADUATE TRAINEE AT OBSTETRICS AND GYNAECOLOGY DEPARTMENT, KRL HOSPITAL, ISLAMABAD.

Irum Sohail, KAHUTA RESEARCH LABORATORIES (KRL), HOSPITAL, ISLAMABAD, PAKISTAN.

PROFESSOR AT OBSTETRICS AND GYNAECOLOGY DEPARTMENT, KRL HOSPITAL, ISLAMABAD.

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