ROLE OF C-REACTIVE PROTEIN IN DIAGNOSING NEONATAL SEPSIS
KHYBER MEDICAL UNIVERSITY JOURNAL 2012;4(4)
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Jan, A., Zahid, S., & Ahmad, S. (2012). ROLE OF C-REACTIVE PROTEIN IN DIAGNOSING NEONATAL SEPSIS. KHYBER MEDICAL UNIVERSITY JOURNAL, 4(4), 161-164. Retrieved from https://www.kmuj.kmu.edu.pk/article/view/10915

Abstract

Objective: To determine the sensitivity and specificity of C-reactive protein (CRP) in diagnosing neonatal sepsis.

Methodology: A cross sectional study of neonates suspected to have sepsis was carried out in the neonatology department of Rehman Medical Institute Peshawar Pakistan. The duration of study was from 1stJan, 2010 to 31st Dec, 2011. A total of 300 cases were selected who were fulfilling the criteria for neonatal sepsis. C-reactive protein and blood cultures were done in all cases following a standard protocol.

Results: Among 300 neonates selected, sepsis was confirmed among 56 % (167 of 300) cases. This was done on the basis of positive blood culture. In 66% (198 of 300) cases C-reactive protein was positive with the Sensitivity, specificity, negative and positive predictive values of 94.01%, 69.17%, 79.29%, 90.19% respectively. The diagnostic accuracy of CRP was 83.0%.

Conclusion: C-reactive protein is a good diagnostic test index and can identify the infection in neonates at the time of initial assessment.

Key Words: Neonatal Sepsis, C-Reactive Proteins, Blood Cultures

 

This article may be cited as: Jan AZ, Zahid SB, Ahmad S. Role of C-reactive protein in diagnosing neonatal sepsis. Khyber Med Univ J 2012; 4(4): 161-164.

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References

Mathai E, Christopher U, Mathai M, Jana AK, Rose

D, Bergstrom S. Is C-reactive protein level useful

in differentiating infected from uninfected neonates

among those at risk of infection? Indian Pediatrics 2004;

(9):895–900.

Gotoff SP. Neonatal sepsis and meningitis. Nelson Text

book Pediatrics, 16th edn. W.B.Saunders Philadelphia,

; 798-800.

Aurangzeb B, Hameed A. Neonatal sepsis in hospital

borne-babies; bacterial isolates and antibiotic susceptibility

patterns. J Coll Physicians Surg Pak 2003; 13(11):

- 32.

Bangladesh Demographic and Healthsurvey 2004.

National Institute of Population Research and Training

(NIPORT) Dhaka, Bangladesh.

Bacterial etiology of serious infections in young infants

in developing countries: results of a multicenter study.

The WHO Young Infants Study Group. Pediatr Infect Dis

J 1999, 18(10 Suppl.):S17–22.

Hammerschlag MR, Klein JO, Herschel M, Chen FC,

Fermin R: Patterns of use of antibiotics in two newborn

nurseries N Engl J Med 1977; 296:1268-9.

Philip AG, Hewitt JR: Early diagnosis of neonatal sepsis.

Pediatrics 1980, 65:1036-41.

Gerdes JS, Polin RA: Sepsis screen in neonates with

evaluation of plasma fibronectin. Pediatr Infect Dis J

, 6:443-6.

Ehl S Gering B, Bartmann P, Högel J, Pohlandt F. C-reactive

protein is a useful marker for guiding duration of antibiotic therapy in suspected neonatal bacterial

infection. Pediatrics 1997, 99:216–21.

Clyne B, Olshaker JS. The C-reactive protein. J Emerg

Med 1999; 17:1019-25.

Marshal SE. Immunological factors in diseases. In : Boon

NA, Cooledge NR, Walker BR, et al. editors . Davidson

’s principles and practice of medicine. 20thed . Churchill

Livingstone ; 2006. p. 63-91.

Ananthakrishnan S . Gunasekaran D. Etiology and risk

factors for early onset neonatal sepsis, Indian J Med

Microbiol 2009;27(3):279.

Rodwell RL. Taylor KM, Tudehope DI, Gray PH. Hematological Scoring system in early diagnosis of sepsis in

neutopenic newborns. Pediatr infect Dis J 1993; 12:372-6

Abdollahi A, Shoar S, Nayyeri F, Shariat M. Diagnostic

value of simultaneous measurement of Procalcitonin,

Interleukin-6 and hs-CRP in prediction of early-onset

neonatal sepsis. Mediterr J Hematol Infect Dis 2012; 4;

:e2012028. Epub 2012 May 6.

Naher BS, Mannan MA, Noor K, Shahiddullah M. Role

of serum procalcitonin and C-Reactive Protein in the

diagnosis of neonatal sepsis. Bangladesh Med Res

Counc Bull 2011; 37: 40-6.

Pavcnik-Arnol M, Hojker S, Derganc M. Lipopolysaccharide-binding protein in critically ill neonates and children with suspected infection: comparison with procalcitonin, interleukin-6, and C-reactive protein Intensive Care Med 2004;30:1454-60.

Benitz WE, Han MY, Madan A, Ramachandra P. Serial

serum C-reactive protein levels in the diagnosis of neonatal

infection. Pediatrics 1998;102(4):E41.

Boraey NF, Sheneef A, Mohammad MAA, Yousef LM.

Procalcitonin and C-Reactive Protien as diagnostic

marker of neonatal sepsis, Austral J Basic Applied Sci

; 6(4): 108-114.

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