CHANGES IN RETINAL NERVE FIBER LAYER ON OPTICAL COHERENCE TOMOGRAPHY AFTER PANRETINAL PHOTOCOAGULATION IN PATIENTS WITH PROLIFERATIVE DIABETIC RETINOPATHY

Main Article Content

Muhammad Shaheer
Arooj Amjad
Asima Rafique

Abstract

ABSTRACT

OBJECTIVE: To study changes in retinal nerve fiber layer (RNFL) measured on optical coherence tomography (OCT) after panretinal photocoagulation (PRP) in patients with proliferative diabetic retinopathy (PDR).

METHODS: This quasi experimental study was conducted at Department of Ophthalmology, Lahore General Hospital, Lahore from 1-4-2017 to 30-3-2018. All patients (n=38) diagnosed with PDR requiring PRP were included. Patients having any coexisting ocular pathology hindering the OCT measurement were excluded. Pre-operatively, RNFL thickness in four quadrants and signal strength was measured on OCT and visual acuity (VA) on Snellen’s chart. Post-operatively, patients were followed-up after one-month and three-months and VA was measured and OCT performed. 

RESULTS: The mean age of patients was 60.66±5.51years with 23(60.5%)males. PRP was performed in right-eye of 22 patients. Pre-laser VA in 28 patients was 6/60. Pre-laser total RNFL was 84.32±4.78µm reduced to 83.74±4.61µm one-month and 81.89±4.40µm three-months post-laser (p<0.001). Pre-laser, superior RNFL thickness was 84.97±4.13µm, reduced to 84.39±3.95µm one-month and to 82.21±3.84µm at three-months post-laser (p 0.024). Pre-laser inferior RNFL thickness was 84.89±4.68µm, reduced to 84.00±4.44µm one-month and to 81.71±4.50µm three months post-laser (p=0.032). Pre-laser temporal RNFL thickness was 83.26±3.47µm, reduced to 82.34±3.44µm one-month and to 80.21±3.49µm three-months post-laser (p<0.001). Pre-laser nasal RNFL thickness was 85.16±3.78µm, reduced to 84.26±3.88µm one-month post-laser and to 82.08±3.74µm at three-months post-laser (p=0.043). Pre-laser, signal strength on OCT was 8.26±0.69 and 8.66±0.48 one-month post-laser and 8.55±0.50 three-months post-laser (p=0.009).

CONCLUSION: PRP leads to a decrease in thickness of RNFL after one month and three months as compared to pre-laser RNFL thickness.

KEY WORDS: Retina (MeSH); Panretinal photocoagulation (Non-MeSH); Retinal nerve fiber layer thickness (Non-MeSH); Diabetic Retinopathy (MeSH); Tomography, Optical Coherence (MeSH); Neovascularization, Pathologic (MeSH); Laser Coagulation (MeSH).

Article Details

How to Cite
Shaheer, Muhammad, et al. “CHANGES IN RETINAL NERVE FIBER LAYER ON OPTICAL COHERENCE TOMOGRAPHY AFTER PANRETINAL PHOTOCOAGULATION IN PATIENTS WITH PROLIFERATIVE DIABETIC RETINOPATHY”. KHYBER MEDICAL UNIVERSITY JOURNAL, vol. 10, no. 4, Dec. 2018, pp. 183-87, doi:10.35845/kmuj.2018.18628.
Section
Original Articles
Author Biographies

Muhammad Shaheer, Lahore General Hospital/ Post Graduate Medical Institute.

Senior Registrar, Department of Ophthalmology

Arooj Amjad, Lahore General Hospital/ Post Graduate Medical Institute.

Senior Registrar, Department of Ophthalmology

Asima Rafique, Mayo Hospital, Lahore

Post Graduate Resident, Department of Ophthalmology

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