HYPOADIPONECTINEMIA AND DYSLIPIDEMIA IN RELATION TO GLYCEMIC STATUS IN TYPE 2 DIABETES AND CORONARY HEART DISEASE

Sadaf Durrani, Jasmin Shah, Mudassir Ahmad Khan, Muhammad Rasul Jan

Abstract


OBJECTIVE: to study the relationship of adiponectin level with lipid
profile and glycemic control in type 2 diabetic subjects with and without
coronary heart disease (CHD).
METHODOLOGY: This cross-sectional/ analytical study consisted of
three groups. Group A consisted of 60 healthy subjects, group B consisted of 60 type 2 diabetic subjects and group C consisted of 60 type
2 diabetic subjects with coronary heart disease. The study participants
were analyzed for serum adiponectin level, triglycerides (TG), total
cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low
density lipoprotein cholesterol (LDL-C), very low density lipoprotein
cholesterol (VLDL-C), fasting blood glucose (FBG) and glycosylated
hemoglobin (HbA1c).
RESULTS: Significantly high adiponectin level was observed in female
subjects as compared to male subjects. Type 2 diabetic subjects with
and without coronary heart disease presented with significantly higher
FBG, HbA1c, TC and TG (p value <0.05) and significantly lower levels
of serum adiponectin and HDL-C (p value <0.001). Adiponectin level
showed significant positive association with HDL-C in control group
(female: r 0.988; p=<0.01, male: r 0.948; p=<0.01), type 2 diabetic
group (female: r 0.908; p=<0.01, male: r 0.860; p=<0.01) and type 2
diabetic group having coronary heart disease (female: 0.775; p=<0.01,
male: 0.650; p=<0.01). Significant (p value <0.01) negative association
of adiponectin was observed with TG, FBG and HbA1c in type 2 diabetic
subjects with and without coronary heart disease.
CONCLUSION: Hypoadiponectinemia in type 2 diabetic subjects with
and without coronary heart disease is related with un-controlled glycemic
status and dyslipidemia.


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