HYPERFIBRINOGENEMIA IN RELATION TO GLYCEMIC STATUS AND DYSLIPIDEMIA IN TYPE 2 DIABETES MELLITUS AND CORONARY HEART DISEASE
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Abstract
OBJECTIVES: To determine plasma fibrinogen level in type 2 diabetic
patients with and without coronary heart disease (CHD) and to find
relationship of fibrinogen with glycemic control and lipid profile in
these patients.
METHODS: A cross-sectional / analytical study was performed among
the outdoor and indoor patients visiting Khyber Teaching Hospital and
Hayatabad Medical Complex, Peshawar, Pakistan. The study consisted
of two groups. Group A was comprised of 100 type 2 diabetic patients
without CHD and group B was comprised of 100 type 2 diabetic patients
with CHD. Biochemical analysis of samples was carried out in
the Research laboratory of Biochemistry Department, Khyber Medical
College, Peshawar. Plasma fibrinogen level was measured by clotting
method and statistical analysis was done on SPSS 19 soft ware.
RESULTS: Mean plasma fibrinogen level was 413.44±139.75 mg/dL
& 478.63±165.97 mg/dL was observed in group-A & group-B respectively
(p<0.05). Mean fasting blood sugar was 175.61±59.13 mg/dL &
213.80±91.62 mg/dL in group-A & group-B respectively (p<0.05). Mean
HbA1C in group-A and group-B was 8.308±3.03% & 10.166±3.452%
respectively (p<0.05). A strong positive association of fibrinogen was
seen with serum triglycerides (p<0.01), total cholesterol (p<0.05) and
body mass index (p<0.01).
CONCLUSION: Fibrinogen levels are elevated in type 2 diabetic patients
with and without coronary heart disease. Moreover, hyperfibrinogenemia
is associated with serum cholesterol, serum triglycerides and BMI
in these patients.
KEY WORDS: Fibrinogen (MeSH); Diabetes Mellitus (MeSH); Hemoglobin
A, Glycosylated (MeSH); Body Mass Index (MeSH); Hyperlipidemias
(MeSH); Cholesterol (MeSH); Triglycerides (MeSH)
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