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of HRT for Men.” Retrieved October 2012 from http://
2. Lo Y. Estimating Age-specific Prevalence of Testosterone
Deficiency in Men Using Normal Mixture Models. J Data
Science 2009; 7: 203-217.
3. Swerdloff RS, Wang C. The testis and male sexual function.
In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th
ed. Philadelphia, Pa: Saunders Elsevier; 2011: pp. 242.
4. Topiwala S. “Testosterone” Retrieved 22nd March, 2012
5. Nahoul K, Roger M. Age-related decline of plasma bioavailable testosterone in adult men. J Steroid Biochem
1990; 35(2): 293-9.
6.Okamura K, Ando F, Shimokata H. Serum total and free
testosterone level of Japanese men: A population-based
study. Int J Urol 2005; 12: 810-4.
7. Sternbach, H. Age-associated testosterone decline in
men: clinical issues for psychiatry. Am J Psychiatry
8. Wang X, Shen CL, Dyson MT, Eimerl S, Orly J, Hutson
JC, et al. Cyclooxygenase-2 regulation of the age-related
decline in testosterone biosynthesis. Endocrinology
2005; 146(10): 4202- 8.
9. Purifoy FE, Koopmans LH, Mayes DM. Age differences
in serum androgen levels in normal adult males. Hum
Biol 1981;53: 499–511.
10. Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman
MR. Baltimore Longitudinal Study of Aging. Longitudinal
effects of aging on serum total and free testosterone
levels in healthy men. J Clin Endocrinol Metab 2001;
11. Travison TG, Araujo AB, Kupelian V, O’Donnell AB,
McKinlay JB. The relative contributions of aging, health,
and lifestyle factors to serum testosterone decline in
men. J Clin Endocrinol Metab 2007; 92: 549-55.
12. Wu FC, Tajar A, Pye SR, Silman AJ, Finn JD, O’Neill TW,
et al. European Male Aging Study Group. Hypothalamic-
pituitary-testicular axis disruptions in older men are
differentially linked to age and modifiable risk factors. J
Clin Endocrinol Metab 2008; 93: 2737-45.
13. Shanti Med spa, Testosterone for Men: Optimal Health
Today. Retrieved November 2012 from http://optimalhealthtoday.
14. Jones GE, Baker K, Fahmy DR, Boyns AR, Leifke E. Effect
of luteinizing hormone releasing hormone on plasma
levels of luteinizing hormone, oestradiol and testosterone
in the male dog. J Endocrinol 1976; 68: 469-474.
15. Leifke E, Gorenoi V, Wichers C, Von Zur Mühlen A, Von
Büren E, Brabant G, et al. Age-related changes of serum
sex hormones, insulin-like growth factor-1 and sex-hormone
binding globulin levels in men: cross-sectional
data from a healthy male cohort. Clin Endocrinol (Oxf).
2000; 53: 689-9.
16. Marcell TJ, Harman SM, Urban RJ, Metz DD, Rodgers
BD, Blackman MR. Comparison of GH, IGF-I, and testosterone
with mRNA of receptors and myostatin in skeletal
muscle in older men. Am J Physiol Endocrinol Metab
2001; 281: 1159-64.
17. St. Louis, Is there a Male ‘Menopause? Retrieved from
December 7, 2012 http://www.usdoctor.com/testone.htm
18. Mazur A, Booth A. “Testosterone and dominance in
men.” Behavioral Brain Sci 1998; 21(3): 353-97.
19. Gapstur SM, Gann PH, Kopp P, Colangelo L, Longcope
C, Liu K. Serum androgen concentrations in young men:
a longitudinal analysis of association with age, obesity
and race. The Cardia Male Hormone Study. Cancer
Epidemiol Biomarkers Preven 2002; 11: 1041-7.
20. Field AE, Colditz GA, Willett WC, Longcope C, Mc-Kinlay
JB. The relation of smoking, age, relative weight and
dietary intake to serum adrenal steroids, sex hormones
and sex hormone-binding globulin in middle-aged men.
J Clin Endocrinol Metab 1994; 79:1310-16.
21. Wang XJ, Dyson MT, Mondillo C, Patrignani Z, Pignataro
O, Stocco DM. Interaction between arachidonic acid and
cAMP signaling pathways enhances steroidogenesis
and StAR gene expression in MA-10 Leydig tumor cells.
Mol Cell Endocrinol 2002; 188: 55–63.
22. Ronco AM, Moraga PF, Llanos MN. Arachidonic acid release
from rat Leydig cells: the involvement of G protein,
phospholipase A2 and regulation of cAMP production.
J Endocrinol 2002; 172: 95–104.
23. Wang X, Walsh LP, Reinhart AJ, Stocco DM. The role of
arachidonic acid in steroidogenesis and steroidogenic
acute regulatory (StAR) gene and protein expression. J
Biol Chem 2000; 275: 20204–9.
24. Wang XJ, Dyson MT, Jo Y, Eubank DW, Stocco DM. Involvement
of 5-lipoxygenase metabolites of arachidonic
acid in cyclic AMP-stimulated steroidogenesis and steroidogenic acute regulatory protein gene expression. J
Steroid Biochem Mol Biol 2003b; 85: 159–66.
25. Shea-Eaton W, Sandhoff TW, Lopez D, Hales DB, McLean
MP. Transcriptional repression of the rat steroidogenic
acute regulatory (StAR) protein gene by the AP-1 family
member c-Fos. Mol Cell Endocrinol 2002; 188: 161–70.
26. Stewart KG, Zhang Y, Davidge ST. Aging increases
PGHS- 2-dependent vasoconstriction in rat mesenteric
arteries. Hypertension 2000; 35: 1242–7.
27. Chung HY, Kim HJ, Kim JW, Yu BP. The inflammation
hypothesis of aging: molecular modulation by calorie
restriction. Ann NY Acad Sci 2001; 928: 327–35.
28. Syntin P, Chen H, Zirkin BR, Robaire B. Gene expression
in Brown Norway rat Leydig cells: effects of age and
of age-related germ cell loss. Endocrinol 2001; 142:
29. Wang XJ, Shen CL, Dyson MT, Hutson JC, Stocco DM.
2003c. Cyclooxygenase-2 and its inhibitors in StAR gene
expression and testosterone biosynthesis in aged male
rats. In: Proceedings of the Annual Healthy Aging Symposium:
Ages and Stages, Lubbock, Texas.
30. Wang XJ, Dyson MT, Jo Y, Stocco DM. Inhibition of cyclooxygenase 2 activity enhances steroidogenesis and
steroidogenic acute regulatory gene expression in MA-10
mouse Leydig cells. Endocrinol 2003a; 144: 3368–75.
31. Gao HB, Shan LX, Monder C, Handy MP. Supression
of endogenous corticosterone levels in vivo increases
the steroidogeneic capacity of purified rat Leidig cells
in vitro. Endocrinol 1996; 137: 1714–8.
32. Roy M, Kirschbaum C, Steptoe A. Intraindividual variation
in recent stress exposure as a moderator of cortisol and
testosterone levels. Ann Behav Med 2003; 26: 194–200.
33. Gao HB, Tong MH, Hu YQ, Guo QS, Ge R, Hardy MP.
Glucocolticoid induces apoptosis in rat Leidig cells.
Endocrinol 2002; 143: 130–8.
34. Midzaka AS, Chen H, Papadopoulos V, Zirkin BR. Leydig cell aging and the mechanisms of reduced testosterone
synthesis. Molecular and Cellular Endocrinology 2009;