SERUM ASPARATATE TRANSAMINASE PLATELET RATIO INDEX (APRI) IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE IN BANGLADESH

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Mir Fowaz Hossain
Mamun Al Mahtab
Fazle Akbar
Salimur Rahman

Abstract

Objective: To correlate serum Aspartate transaminase (AST) and Platelet Ratio Index (APRI) with the degree of hepaticfibrosis in patients with non alcoholic fatty liver disease (NAFLD).

Methodology: This study was conducted on patients with NAFLD presenting at Bangabandhu Sheikh Mujib MedicalUniversity, Dhaka, Bangladesh, from July 2007 to June 2008. In all patients, platelet counts and levels of AST weremeasured in the sera. Percutaneous liver biopsy was done in these patients to assess the levels of hepatic fibrosis(HF). APRI was calculated by using the formula; AST×UNL×100/platelet count×109/L.

Results: Out of 30 patients, 28 had HF score of <2, while 2 had HF score of >2. However, high HF score was notassociated with high AST. Based on platelet count, patients were divided into 2 groups; patients with platelet countsof <150,000/mm3 and those with platelet counts of >150,000/mm3. Sensitivity of APRI (cut off level 1.5) to diagnosesignificant fibrosis was 0%, specificity 96.4%, positive predictive value .0%, negative predictive value 93.1% anddiagnostic accuracy 90.0%. On the other hand, when we considered APRI level of >1.5 as an indicator of significantfibrosis, one person was supposed to have hepatic fibrosis score of >2 from APRI value. But, liver histology of thatperson did not support hepatic fibrosis of >2.

Conclusion: APRI has no correlation with degree of hepatic fibrosis in patients with NAFLD and hence cannot beused as a non-invasive marker of fibrosis in patients with NAFLD in Bangladesh. However large scale studies arerequired to confirm these findings.

Key Words: Aspartate Transaminase Platelet Ratio Index, APRI, Non-Alcoholic Fatty Liver Disease (NAFLD), HepaticFibrosis.

Article Details

How to Cite
Hossain, M., M. Mahtab, F. Akbar, and S. Rahman. “SERUM ASPARATATE TRANSAMINASE PLATELET RATIO INDEX (APRI) IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE IN BANGLADESH”. KHYBER MEDICAL UNIVERSITY JOURNAL, Vol. 4, no. 2, June 2012, pp. 49-53, https://www.kmuj.kmu.edu.pk/article/view/9469.
Section
Original Articles
Author Biographies

Mir Fowaz Hossain

Department of Hepatology, Mymensingh Medical College, Mymensingh, Bangladesh

Mamun Al Mahtab, Bangabandhu Sheikh Mujib Medical University

Assistant Professor, Department of Hepatology

Bangabandhu Sheikh Mujib Medical University
Consultant Hepatologist, Gastroenterologist & Interventional Endoscopist
Liver Clinic, Lab Aid Specialized Hospital
Dhaka, Bangladesh

Fazle Akbar

Department of Medical Sciences, Toshiba General Hospital, Tokyo, Japan

Salimur Rahman

Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh