Main Article Content
Researchers from the developed world usually carry out various biomedical research in developing countries. Citizens of these developing countries are used as research subjects and therefore are exposed to different experiments which risk them to negative effects of the studies while the net benefit is transferred to the developed world. This article highlights the different ethical and moral issues in biomedical research involving the use of human subjects. It will further suggest strategies to make such types of research, ethical and to protect the human rights.
Key Words: Biomedical Research (MeSH), Ethics (MeSH), Bioethical Issues (MeSH)
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1. Barr DA, Field MG. The current state of health care in the former Soviet Union: implications for health care policy and reform. Am J Public Health 1996 Mar;86(3):307-12.
2. Hamel JY. ICT4D and the human development and capabilities approach: The potentials of information and communication technology. United Nations Development Programme. Human Development Reports Research Paper. September 2010. [Cited on October 08, 2015]. Available from URL: http://hdr.undp.org/sites/default/files/hdrp_2010_37.pdf
3. Trials of war criminals before the Nuremberg military tribunals under control council law no. 10. Nuremberg, October 1946–April 1949. Washington, D.C.: U.S. G.P.O, 1949–1953.
4. World Medical Association. World medical association declaration of Helsinki: Ethical principles for medical research involving human subjects. JAMA 2013 ; 310(20 2191):2191-4. [Cited on October 08, 2015]. Available from URL: https://www.wma.net/wp-content/uploads/2016/11/DoH-Oct2013-JAMA.pdf
5. National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. The Belmont Report: Ethical Principles and Guidelines for the Protection of Human Subjects of Research. DHEW Publication No. (OS) 78-0012. [Cited on October 08, 2015]. Available from URL: https://videocast.nih.gov/pdf/ohrp_appendix_belmont_report_vol_2.pdf
6. The Council for International Organizations of Medical Sciences (CIOMS). International Ethical Guidelines for Biomedical Research Involving Human Subjects. CIOMS, Geneva 2002. [Cited on October 08, 2015]. Available from URL: http://www.cioms.ch/publications/ guidelines/guidelines_nov_2002_blurb. Htm
7. Angell M. The ethics of clinical research in the Third World. N Engl J Med. 1997 Sep 18;337(12):847-9.
8. Curran WJ. The Tuskegee syphilis study. N Engl J Med 1973; 289(14):730-1.
9. Connor EM, Sperling RS, Gelber R, Kiselev P, Scott G, O'Sullivan MJ, et al. Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. N Engl J Med. 1994 Nov 3;331(18):1173-80.
10. Thea DM. Ethical issues in the use of zidovudine to reduce vertical transmission of HIV. N Engl J Med. 1995 Mar 30;332(13):892.
11. Merson MH. Ethics of placebo-controlled trials of zidovudine to prevent the perinatal transmission of HIV in the Third World. N Engl J Med. 1998 Mar 19;338(12):836; author reply 840-1.
12. Lurie P, Wolfe SM. Unethical trials of interventions to reduce perinatal transmission of the human immunodeficiency virus in developing countries. N Engl J Med. 1997 Sep 18;337(12):853-6.
13. Bhutta ZA. Ethics in international health research: a perspective from the developing world. Bull World Health Organ 2002;80(2):114-20.
14. Bankowski Z, Levine RJ. Ethics and research on human subjects: international guidelines. Proceedings of the XXVIth CIOMS Conference, Geneva, Switzerland 5-7 February 1992. In Ethics and research on human subjects: international guidelines. Proceedings of the XXVIth CIOMS Conference, Geneva, Switzerland 5-7 February 1992. Council for International Organizations of Medical Sciences (CIOMS).
15. Hughes RC. Justifying community benefit requirements in international research. Bioethics. 2014 Oct; 28(8):397-404.
16. Wendler D, Shah S. Involving Communities in Deciding What Benefits They Receive in Multinational Research. J Med Philos 2015;40(5):584-600. doi:10.1093/jmp/jhv017.
17. Srinivasan S, Nikarge S. "Ethical concerns in clinical trials in India: An investigation." Centre for studies in ethics and rights (CSER). 2009. Mumbai. [Cited on October 08, 2015]. Available from URL: http://environmentportal.in/files/Ethical_concerns_in_clinical_trials_in_India_An_investigation.pdf
18. Emanuel EJ, Wendler D, Killen J, Grady C. What makes clinical research in developing countries ethical? The benchmarks of ethical research. J Infect Dis 2004 Mar 1;189(5):930-7.
19. Zong Z. Should post-trial provision of beneficial experimental interventions be mandatory in developing countries? J Med Ethics 2008 Mar 1;34(3):188-92.
20. Shaffer DN, Yebei VN, Ballidawa JB, Sidle JE, Greene JY, Meslin EM, et al. Equitable treatment for HIV/AIDS clinical trial participants: a focus group study of patients, clinician researchers, and administrators in western Kenya. J Med Ethics 2006 Jan 1;32(1):55-60.