Seropositivity of Toxoplasma gondii latent infection in patients with neuropsychiatric disorders

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Aziz Marjan Kahttak
Jafar Khan
Hazir Rahman


 OBJECTIVE: To detect Toxoplasma latent infection seropositivity as an­ti-toxoplasma antibodies and its serointensity as anti-toxoplasma gondii IgG (ATG-IgG) levels in target groups with neuropsychiatry diseases.

METHODOLOGY: This prospective cross sectional study was conducted from September 2013 to August 2014. Target subjects were taken from Kohat and Karak districts. Cases were in grouped in A & B per selection criteria with healthy control. Group A included children with mental retardation & group B included adult patients using neuropsychiatric drugs. Latex agglutination and ELISA tests were run on blood samples for ATG-IgG.

RESULTS: Group A included 69 patients and 36 controls with mean age of 8.61±2.09 & 8.42±1.71 years respectively. ATG-IgG were positive in 17/69(24.6%) cases and 5/36(13.9%) controls (p>0.05). Mean value of ELISA (IU/ml) for ATG-IgG was 43.56±12.87 for positive cases and 11.84±8.45 for negative. There was gradual increase in mean value of ELISA for mild, moderate, severe as 17.11, 21.08 and 32.94 respectively.

Group B included 73 patients and 40 controls with mean age of 31.88±11.35 & 31.82± 9.95 years respectively. ATG-IgG were positive in 41/73(56.2%) cases and 7/40 (17.5%) controls (p<0.01). Among cases, 41 while, among controls 7 were positives for ATG-IgG. The mean value of ELISA (IU/ml) was 102.80±89.52 and for negative cases 11.362±7.11. The mean value of ELISA for degree of disease presentation as mild moderate and severe was 37.72, 64.65, and 88.31 respectively.

CONCLUSION: Significant number of patients with psychiatric disorders expressed seropositivity for anti T. plasma antibodies. Antibodies levels increase with severity of psychosis.

KEY WORDS: Latent infection, Toxoplasma gondii, Neuropsychiatric disorders.

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How to Cite
Kahttak, A., J. Khan, and H. Rahman. “Seropositivity of Toxoplasma Gondii Latent Infection in Patients With Neuropsychiatric Disorders”. KHYBER MEDICAL UNIVERSITY JOURNAL, Vol. 7, no. 1, Mar. 2015, pp. 14-18,
Original Articles


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