ASSOCIATION OF IRON STATUS WITH FEBRILE SEIZURES
KHYBER MEDICAL UNIVERSITY JOURNAL 2012;4(4)
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How to Cite

, A., Ali, M., Maqsood, S., & QURESHI, M. (2012). ASSOCIATION OF IRON STATUS WITH FEBRILE SEIZURES. KHYBER MEDICAL UNIVERSITY JOURNAL, 4(4), 170-173. Retrieved from https://www.kmuj.kmu.edu.pk/article/view/10837

Abstract

Objective: to investigate the relationship of iron status and febrile seizures (FS).

Methodology: This case control study was conducted at Military Hospital Rawalpindi, from January 2006 to January 2007. Indicators of iron deficiency including hemoglobin, Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), and plasma ferritin levels (FL) were prospectively studied in 60 children with first febrile seizures compared with 60 controls with febrile illness without convulsions.

Results: In the FS group, the mean hemoglobin was 8.96±1.6 gm/dL, the mean MCV was 64.9± 8.39 fL, mean MCH was 21.36±3.65 pg and mean FL were 4.4±2.44 ng/dL. In the control group the mean hemoglobin was 10.9±1.79 gm/ dL, the mean MCV was 74.98±8.49 fL, MCH was 26.55±4.59 pg and mean FL were 14.87±6.47 ng/dL (p=0.005). In the FS group, 48 (80%) children had low hemoglobin <10 gm/dL, 45 (75%) had a low MCV <70 fL, 47 (78.3%) had a low MCH <24 pg and 48 (80%) had a low FL <10 ng/dL. In the control group, 18 (30%) children had low hemoglobin <10 gm/dL, 17 (28.3%) had a low MCV <70 fL, 18 (30.3%) had a low MCH <24 pg and 19 (31.7%) had a low FL of <10 ng/dL (p <0.005). Mean peak temperature was 38.35 ±0.40 C0 & 38.12 ± 0.41 C0 in FS group and controls respectively (p < 0.005).

Conclusion: Hemoglobin, MCV, MCH, and plasma FL were significantly lower in children with febrile seizures than in control group suggesting a possible role for iron deficiency in febrile seizures.

Key words: iron deficiency anemia; febrile seizures; plasma ferritin

This article may be cited as: Ameenullah, Ali MA, Maqsood SU, Ahmed MT. Association of iron status with febrileseizures. Khyber Med Univ J 2012; 4(4): 170-173.

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References

Paul SP, Blaikley S, Chinthapalli R. Clinical update:

febrile convulsion in childhood. Community Pract 2012;

:36-8.

Winawer M, Hesdorffer D. Turning on the heat:

The search for febrile seizure genes. Neurology

;63:1770-1.

Wo SB, Lee JH, Lee YJ, Sung TJ, Lee KH, Kim SK. Risk

of developing epilepsy and epileptiform discharges on

EEG in patients with febrile seizures. Brain Dev Epub

Aug 11.

Bamberg R. Occurrence and detection of iron-deficiency

anemia in infants and toddlers. Clin Lab Sci

;21:225-31.

Ikram M, Bai A. Iron deficiency anemia: Evaluation &

management in primary care. Med Today 2004;2:45-51.

De-Regil LM, Jefferds ME, Sylvetsky AC, Dowswell T.

Intermittent iron supplementation for improving nutrition

and development in children under 12 years of age. Cochrane Database Syst Rev. 2011:7;:CD009085.

Derakhshanfar H, Abaskhanian A, Alimohammadi H,

Modanlookordi M. Association between iron deficiency

anemia and febrile seizure in children. Med Glas Ljek

Komore Zenicko-Doboj Kantona 2012;9:239-42.

Sherjil A, Saeed Z US, Shehzad S, Amjad R. Iron

deficiency anaemia--a risk factor for febrile seizures in

children. J Ayub Med Coll Abbottabad 2010;22:71-3.

Naveed-ur-Rehman, Billoo AG. Association between

iron deficiency anemia and febrile seizures. J Coll

Physicians Surg Pak 2005;15:338-40.

Mikati MA, Rahi A: Febrile seizures: From molecular

biology to clinical practice. Neurosciences 2004;10:14–

Kim JA, Connors BW. High temperatures alter physiological properties of pyramidal cells and inhibitory

interneurons in hippocampus. Front Cell Neurosci

;6:27.

Teran CG, Medows M, Wong SH, Rodriguez L, Varghese

R. Febrile seizures: Current role of the laboratory

investigation and source of the fever in the diagnostic

approach. Pediatr Emerg Care 2012;28:493-7.

Siddiqui ST. Febrile convulsions in children: Relationship

of family history to type of convulsions and age at

presentation. J Ayub Med Coll Abottabad 2002;14:26-8.

Birca A, Guy N, Fortier I, Cossette P, Lortie A, Carmant

L. Genetic influence on the clinical characteristics and

outcome of febrile seizures--a retrospective study. Eur

J Paediatr Neurol 2005;9:339-45.

Wike WM, Kiser WR. Iron deficiency anemia and febrile

convulsion: Possible counfounding factor include lead

toxicity. BMJ 1996; 313: 1205.

Rahman MA, Rahman B, Ahmad MS, Blann A, Ahmed N.

Blood and hair lead in children with different extents of

iron deficiency in Karachi. Environ Res 2012;118:94-100.

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