Objective: to investigate the relationship of iron status and febrile seizures (FS).
Methodology: This case control study was conducted at Military Hospital Rawalpindi, from January 2006 to January 2007. Indicators of iron deficiency including hemoglobin, Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), and plasma ferritin levels (FL) were prospectively studied in 60 children with first febrile seizures compared with 60 controls with febrile illness without convulsions.
Results: In the FS group, the mean hemoglobin was 8.96±1.6 gm/dL, the mean MCV was 64.9± 8.39 fL, mean MCH was 21.36±3.65 pg and mean FL were 4.4±2.44 ng/dL. In the control group the mean hemoglobin was 10.9±1.79 gm/ dL, the mean MCV was 74.98±8.49 fL, MCH was 26.55±4.59 pg and mean FL were 14.87±6.47 ng/dL (p=0.005). In the FS group, 48 (80%) children had low hemoglobin <10 gm/dL, 45 (75%) had a low MCV <70 fL, 47 (78.3%) had a low MCH <24 pg and 48 (80%) had a low FL <10 ng/dL. In the control group, 18 (30%) children had low hemoglobin <10 gm/dL, 17 (28.3%) had a low MCV <70 fL, 18 (30.3%) had a low MCH <24 pg and 19 (31.7%) had a low FL of <10 ng/dL (p <0.005). Mean peak temperature was 38.35 ±0.40 C0 & 38.12 ± 0.41 C0 in FS group and controls respectively (p < 0.005).
Conclusion: Hemoglobin, MCV, MCH, and plasma FL were significantly lower in children with febrile seizures than in control group suggesting a possible role for iron deficiency in febrile seizures.
Key words: iron deficiency anemia; febrile seizures; plasma ferritin
This article may be cited as: Ameenullah, Ali MA, Maqsood SU, Ahmed MT. Association of iron status with febrileseizures. Khyber Med Univ J 2012; 4(4): 170-173.
Paul SP, Blaikley S, Chinthapalli R. Clinical update:
febrile convulsion in childhood. Community Pract 2012;
Winawer M, Hesdorffer D. Turning on the heat:
The search for febrile seizure genes. Neurology
Wo SB, Lee JH, Lee YJ, Sung TJ, Lee KH, Kim SK. Risk
of developing epilepsy and epileptiform discharges on
EEG in patients with febrile seizures. Brain Dev Epub
Bamberg R. Occurrence and detection of iron-deficiency
anemia in infants and toddlers. Clin Lab Sci
Ikram M, Bai A. Iron deficiency anemia: Evaluation &
management in primary care. Med Today 2004;2:45-51.
De-Regil LM, Jefferds ME, Sylvetsky AC, Dowswell T.
Intermittent iron supplementation for improving nutrition
and development in children under 12 years of age. Cochrane Database Syst Rev. 2011:7;:CD009085.
Derakhshanfar H, Abaskhanian A, Alimohammadi H,
Modanlookordi M. Association between iron deficiency
anemia and febrile seizure in children. Med Glas Ljek
Komore Zenicko-Doboj Kantona 2012;9:239-42.
Sherjil A, Saeed Z US, Shehzad S, Amjad R. Iron
deficiency anaemia--a risk factor for febrile seizures in
children. J Ayub Med Coll Abbottabad 2010;22:71-3.
Naveed-ur-Rehman, Billoo AG. Association between
iron deficiency anemia and febrile seizures. J Coll
Physicians Surg Pak 2005;15:338-40.
Mikati MA, Rahi A: Febrile seizures: From molecular
biology to clinical practice. Neurosciences 2004;10:14–
Kim JA, Connors BW. High temperatures alter physiological properties of pyramidal cells and inhibitory
interneurons in hippocampus. Front Cell Neurosci
Teran CG, Medows M, Wong SH, Rodriguez L, Varghese
R. Febrile seizures: Current role of the laboratory
investigation and source of the fever in the diagnostic
approach. Pediatr Emerg Care 2012;28:493-7.
Siddiqui ST. Febrile convulsions in children: Relationship
of family history to type of convulsions and age at
presentation. J Ayub Med Coll Abottabad 2002;14:26-8.
Birca A, Guy N, Fortier I, Cossette P, Lortie A, Carmant
L. Genetic influence on the clinical characteristics and
outcome of febrile seizures--a retrospective study. Eur
J Paediatr Neurol 2005;9:339-45.
Wike WM, Kiser WR. Iron deficiency anemia and febrile
convulsion: Possible counfounding factor include lead
toxicity. BMJ 1996; 313: 1205.
Rahman MA, Rahman B, Ahmad MS, Blann A, Ahmed N.
Blood and hair lead in children with different extents of
iron deficiency in Karachi. Environ Res 2012;118:94-100.
Work published in KMUJ is licensed under a
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.