TY - JOUR AU - Afridi, Mohammad Abdur Rahman AU - Ahmad, Aftab AU - Ali, Zafar AU - Farooqi, Javed Iqbal AU - Mohammad, Riaz AU - Alam, Intekhab PY - 2014/12/18 Y2 - 2024/03/29 TI - Comparative Study of Branched Chain Amino Acids Infusion with Conventional treatment in patients with Hepatic Encephalopathy due to Liver Cirrhosis JF - KHYBER MEDICAL UNIVERSITY JOURNAL JA - Khyber Med Univ J VL - 6 IS - 4 SE - Original Articles DO - UR - https://www.kmuj.kmu.edu.pk/article/view/13939 SP - 163-166 AB - <p><strong>OBJECTIVE</strong>: To determine the effectiveness of branched chain amino<br />acid (BCAA) infusion with conventional therapy in the treatment of<br />hepatic encephalopathy (HE) due to liver cirrhosis.</p><p><br /><strong>METHODOLOGY</strong>: This was a hospital based randomized controlled<br />trial, conducted in the department of medicine, Lady Reading Hospital,<br />Peshawar from February 2012 to July 2012.<br />A total number of 86 patients, of either gender, presenting with grade<br />II, III and IV HE due to cirrhosis were included in the study. They were<br />randomly allocated into two groups by lottery method. Forty three<br />patients in group A were subjected to conventional treatment plus infusion of BCAA (Aminoleban, Otsuka); while 43 patients in group B were<br />subjected to conventional treatment only, which consisted of antibiotics<br />and lactulose. Data analysis was performed using SPSS version 20. ‘Chi<br />square’ test was used to compare the effectiveness in both groups with<br />p value of &lt; 0.05 as significant.</p><p><br /><strong>RESULTS</strong>: Out of 86 patients included in the study, 52(60.5%) were<br />males and 34 (39.5%) were females. Mean age of the sample was<br />49.73±7.958 years with age range from 35 to 70 years. After the administration of BCAA infusion twice daily for 3 days, clinical improvement was observed in 33 (76.7%) patients in group A while in group B only 10 (23.3%) patients improved clinically, showing p-value &lt;0.001.</p><p><br /><strong>CONCLUSION</strong>: Branched chain amino acids infusion is more effective<br />than conventional therapy in the treatment of HE due to liver cirrhosis.</p><p><strong>KEY WORDS:</strong> Hepatic Encephalopathy, Chronic Liver Disease, Branched Chain Amino acids.</p> ER -