@article{Hussain_Malik_Zaheer_Chiragh_2018, title={EFFECT OF PIOGLITAZONE AND GEMFIBROZIL ADMINISTRATION ON C-REACTIVE PROTEIN LEVELS IN NON-DIABETIC HYPERLIPIDEMIC RATS}, volume={10}, url={https://www.kmuj.kmu.edu.pk/article/view/17980}, DOI={10.35845/kmuj.2018.17980}, abstractNote={<p><strong>ABSTRACT</strong></p><p><strong>OBJECTIVE:</strong> To assess and compare anti-inflammatory effect of pioglitazone and gemfibrozil by measuring C-reactive protein (CRP) levels in high fat fed non-diabetic rats.</p><p><strong>METHODS:</strong> A comparative animal study was conducted at the Post Graduate Medical Institute, Lahore, Pakistan in which 27, adult healthy male <em>Sprague Dawley</em> rats were used. The rats were divided into three groups. Hyperlipidemia was induced in all three groups by giving hyperlipidemic diet containing cholesterol 1.5%, coconut oil 8.0% and sodium cholate 1.0%. After four weeks, Group A (control) was given distilled water, Group B was given pioglitazone 10mg/kg body weight and Group C was given gemfibrozil 10mg/kg body weight as single morning dose by oral route for four weeks. CRP was estimated at zero, 4<sup>th</sup> and 8<sup>th</sup> week.</p><p><strong>RESULTS: </strong>There was significant increase in the level of CRP after giving high lipid diet from mean±SD of 2.59±0.28mg/L, 2.63±0.32mg/L and 2.67±0.23mg/L at 0 week to 3.55±0.44mg/L, 3.59±0.34mg/L and 3.6±0.32mg/L at 4<sup>th</sup> week  in groups A, B and C respectively.</p><p>Multiple comparisons by ANOVA revealed significant difference between groups at 8<sup>th</sup> week only.  <em>Post hoc</em> analysis disclosed that CRP level was significantly low in pioglitazone treated group having mean±SD of 2.93±0.33mg/L compared to control group’s 4.42±0.30mg/L and gemfibrozil group’s 4.28±0.39mg/L. The p-value in each case was <0.001, while difference between control and gemfibrozil was not statistically significant.</p><p><strong>CONCLUSION</strong>: Pioglitazone is effective in reducing hyperlipidemia associated inflammation, evidenced by decreased CRP level while gemfibrozil is not effective.</p><p><strong>KEY WORDS:</strong> <span class="fontstyle0">Pioglitazone (MeSH); Gemfibrozil (MeSH);</span> Hyperlipidemia (MeSH); Anti-inflammatory (MeSH); C-reactive protein (MeSH).</p>}, number={3}, journal={KHYBER MEDICAL UNIVERSITY JOURNAL}, author={Hussain, Mazhar and Malik, Mahwash and Zaheer, Zujaja and Chiragh, Sadia}, year={2018}, month={Sep.}, pages={131–34} }