@article{Mushtaq_Kausar_Kousar_Chiragh_2017, title={EFFECT OF AJWA DATE SEED ON LIPID PROFILE OF DIET INDUCED HYPERLIPIDEMIC RABBITS}, volume={9}, url={https://www.kmuj.kmu.edu.pk/article/view/17548}, abstractNote={<p><strong>OBJECTIVE:  </strong>To evaluate the antihyperlipedemic effect of Ajwa date (<em>Phoenix dactylifera</em>) seed on serum lipid levels of diet induced hyperlipidemic rabbits.<strong></strong></p><p><strong>METHODS: </strong> This randomized controlled study of six months’ duration was carried out at Postgraduate Medical Institute, Lahore after obtaining permission from institutional ethical committee. Sample size was calculated at 90% power of study and 5% level of significance. Male rabbits, 32 in number weighing between 0.9-1.3 kg were divided into four groups normal control (NC), high fat diet (HFD), HFD+2%Ajwa date seed powder (HFD+2%A) and HFD+4% Ajwa date seed powder (HFD+4%A) having 8 rabbits in each group. Group NC took normal diet while all other groups were given high fat diet for whole 12 weeks. After 4 weeks groups HFD+2%A and HFD+4%A; were given diet containing Ajwa date seed powder 2gm and 4gm per 100 gm of high fat diet respectively for next 8 weeks. Lipid profile was done at 0, 4, 8 and 12 weeks.</p><p><strong>RESULTS: </strong>Serum high density lipoprotein cholesterol (HDL) is increased while serum cholesterol, triglycerides, low density lipoprotein cholesterol (LDL), atherogenic index of plasma and LDL/HDL ratio decreased significantly in both treatment groups. At 8<sup>th</sup> week HFD+4%A was more effective than HFD+2%A but at 12<sup>th</sup> week both were equally effective.<strong></strong></p><p><strong>CONCLUSION: </strong>Ajwa date seeds were effective in improving the lipid profile despite high fat diet.<strong></strong></p><p><strong>KEY WORDS:</strong> Diet, High-Fat (MeSH), Dyslipidemias (MeSH), Phoeniceae (MeSH), Ajwa Date Seed (Non-MeSH), Seeds (MeSH), Phoenix dactylifera (MeSH).</p>}, number={3}, journal={KHYBER MEDICAL UNIVERSITY JOURNAL}, author={Mushtaq, Zobia and Kausar, Samina and Kousar, Naheeda and Chiragh, Sadia}, year={2017}, month={Oct.}, pages={135–139} }