HYPOADIPONECTINEMIA AND DYSLIPIDEMIA IN RELATION TO GLYCEMIC STATUS IN TYPE 2 DIABETES AND CORONARY HEART DISEASE

Main Article Content

Sadaf Durrani
http://orcid.org/0000-0002-3472-4811
Jasmin Shah
Mudassir Ahmad Khan
Muhammad Rasul Jan

Abstract

OBJECTIVE: to study the relationship of adiponectin level with lipid
profile and glycemic control in type 2 diabetic subjects with and without
coronary heart disease (CHD).
METHODOLOGY: This cross-sectional/ analytical study consisted of
three groups. Group A consisted of 60 healthy subjects, group B consisted of 60 type 2 diabetic subjects and group C consisted of 60 type
2 diabetic subjects with coronary heart disease. The study participants
were analyzed for serum adiponectin level, triglycerides (TG), total
cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low
density lipoprotein cholesterol (LDL-C), very low density lipoprotein
cholesterol (VLDL-C), fasting blood glucose (FBG) and glycosylated
hemoglobin (HbA1c).
RESULTS: Significantly high adiponectin level was observed in female
subjects as compared to male subjects. Type 2 diabetic subjects with
and without coronary heart disease presented with significantly higher
FBG, HbA1c, TC and TG (p value <0.05) and significantly lower levels
of serum adiponectin and HDL-C (p value <0.001). Adiponectin level
showed significant positive association with HDL-C in control group
(female: r 0.988; p=<0.01, male: r 0.948; p=<0.01), type 2 diabetic
group (female: r 0.908; p=<0.01, male: r 0.860; p=<0.01) and type 2
diabetic group having coronary heart disease (female: 0.775; p=<0.01,
male: 0.650; p=<0.01). Significant (p value <0.01) negative association
of adiponectin was observed with TG, FBG and HbA1c in type 2 diabetic
subjects with and without coronary heart disease.
CONCLUSION: Hypoadiponectinemia in type 2 diabetic subjects with
and without coronary heart disease is related with un-controlled glycemic
status and dyslipidemia.

Article Details

How to Cite
Durrani, S., J. Shah, M. A. Khan, and M. R. Jan. “HYPOADIPONECTINEMIA AND DYSLIPIDEMIA IN RELATION TO GLYCEMIC STATUS IN TYPE 2 DIABETES AND CORONARY HEART DISEASE”. KHYBER MEDICAL UNIVERSITY JOURNAL, vol. 6, no. 4, Dec. 2014, pp. 157-62, https://www.kmuj.kmu.edu.pk/article/view/13931.
Section
Original Articles
Author Biography

Sadaf Durrani, Biochemistry Department, Khyber Medical College. Peshawar. KPK.

Demonstrato, Biochemistry Department. Khyber Medical College, Peshawar. KPK.Pakistan.

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